Diallyl trisulfide

한글명:Diallyl trisulfide

카스 번호2050-87-5

상품명:Diallyl trisulfide

CBNumberCB2269270

분자식C6H10S3

포뮬러 무게178.34

MOL 파일2050-87-5.mol

화학적 성질

끓는 점	bp6 92°; bp0.0008 66-67°
밀도	1.085
FEMA	3265 \| DIALLYL TRISULFIDE
굴절률	nD20 1.5896
저장 조건	-20°C
용해도	Soluble in acetone, Ethanol(~3 mg/ml), DMSO (~5 mg/ml), and DMF (~10 mg/ml).
물리적 상태	기름
냄새	프로필렌 글리콜 중 0.10%. 마늘 파 메탈릭
?? ??	유황의
수용성	물에 불용성.
JECFA Number	587
InChI	InChI=1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
InChIKey	UBAXRAHSPKWNCX-UHFFFAOYSA-N
SMILES	S(SCC=C)SCC=C
LogP	4.59
CAS 데이터베이스	2050-87-5(CAS DataBase Reference)
NIST	Trisulfide, di-2-propenyl(2050-87-5)

위험 및 안전 성명

유엔번호(UN No.)

2810

WGK 독일

RTECS 번호

BC6168000

위험 등급

6.1(b)

포장분류

III

HS 번호

29309090

NFPA 704:

	3
2		0

그림문자(GHS)

Diallyl trisulfide 화학적 특성, 용도, 생산

개요
Hydrogen sulfide (H2S) is an endogenously-produced gaseous second messenger that can regulate many physiological processes. Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic that acts as an H2S donor. It reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM). DATS suppresses the growth of PC-3 xenografts in vivo in mice and induces vascular smooth muscle relaxation. Garlic extracts also lower cholesterol and there is evidence that DATS can alter the expression of genes and inhibit enzymes that are relevant to cholesterol synthesis.
화학적 성질
Diallyl trisulfide is a yellow liquid with a disagreeable odor. It is a stable transformation product of allicin. Insoluble in water and ethanol, miscible in ether. Natural products are found in onions, garlic, etc. Diallyl trisulfide (DATS) and diallyl disulfide (DADS) are the two major organosulfides in garlic oil.
출처
Reported found in garlic oil.
용도
Diallyl Trisulfide, is an organosulfur garlic compound that induces neovasculogenesis and has preventive effects against ischemic injuries. Antiarrythmic effect.
제조 방법
In nature, diallyl trisulfide is formed from alliin and allicin.
정의
ChEBI: Diallyl trisulfide is an organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity It has a role as an apoptosis inducer, an estrogen receptor antagonist, an antineoplastic agent, a vasodilator agent, an antioxidant, an anti-inflammatory agent, an insecticide, an antiprotozoal drug, a platelet aggregation inhibitor and an antilipemic drug.
일반 설명
Diallyl trisulfide (DATS) is one of the organosulfur compounds found in garlic (Allium sativum), and other Allium genera such as onions. This sulfur-rich compound is produced by the rapid disintegration of its metabolic precursor Allicin.
Biochem/physiol Actions
DATS is a potent anti-cancer and chemopreventive agent that regulates apoptosis, metastasis, cell cycle, and angiogenesis in cancer pathways. It is also an excellent neuroprotective agent. DATS elicits antioxidant and anti-inflammatory activities against doxorubicin (DOX)-induced rats brains. It may improve glycemic control, muscle glucose utilization, and insulin secretion in streptozotocin-induced diabetic rats.

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