L-(-)-에페드린

한글명:L-(-)-에페드린

카스 번호492-41-1

상품명:L-(-)-Ephedrine

CBNumberCB2159410

분자식C9H13NO

포뮬러 무게151.21

MOL 파일492-41-1.mol

동의어(한글)

L-(-)-에페드린

화학적 성질

녹는점	51-53 °C(lit.)
알파	-41 º (c=7, 1M HCl)
끓는 점	273.23°C (rough estimate)
밀도	1.0406 (rough estimate)
굴절률	1.5380 (estimate)
인화점	>230 °F
저장 조건	2-8°C
물리적 상태	고체
산도 계수 (pKa)	9.958(at 10℃)
optical activity	[α]20/D -41°, c =7 in 1 M HCl
안정성	안정적인. 강한 산화제와 호환되지 않습니다. 빛에 노출되면 변색될 수 있습니다.
CAS 데이터베이스	492-41-1(CAS DataBase Reference)
NIST	Phenylpropanolamine(492-41-1)
EPA	Benzenemethanol, .alpha.-[(1S)-1-aminoethyl]-, (.alpha.R)- (492-41-1)

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	22-36/37/38
안전지침서	26
WGK 독일	3
RTECS 번호	RC2275000
F 고인화성물질	3-8-10
위험 참고 사항	Harmful
독성	LD50 orl-rat: 1538 mg/kg BCFAAI 109,132,70

그림문자(GHS)

L-(-)-에페드린 화학적 특성, 용도, 생산

개요
This alkaloid was first isolated by Kanao from the Chinese drug 'Ma-Huang' (Ephedra sinica Stapf.) and later by Wolfes from E. helvetica C. A. Meyer and E. distachya Linn. It forms a crystalline mass and has [α] ²⁰ _D - 14.56° (EtOH). Several crystalline salts and derivatives are known: the hydrochloride has m.p. 171-2°C; [α] ²⁰ _D- 33.27° (H20); the sulphate dihydrate, m.p. 285-6°C (dry, dec.); [α] ²⁸ _D- 31.99° (H20); the aurichloride, m.p. 188°C; platinichloride, m.p. 221°C (dec.); (-)-hydrogen tartrate, m.p. about 160° after sintering at 130°C; oxalate, m.p. 245°C (dec.) and the p-nitrobenzoyl derivative, m.p. 175-6°C; [α] ²⁸ _D- 49.58° (CHCI3).
The (+)-form has m.p. 52°C; [α] ²⁷ _D + 14.76° (EtOH), yielding a hydro_x0002_chloride, m.p. 171-2°C; [α] ²⁷ _D + 33.4° (EtOH); sulphate dihydrate, m.p. 285- 6°C (dry, dec.); [α] ²⁷ _D+ 31.51 0 C (H20); aurichloride, m.p. 188°C (dec.) and platinichloride, m.p. 221.5°C (dec.). The (±)-form crystallizes as colourless plates from Et20, m.p. 104-5°C and also furnishes a series of crystalline salts and derivatives.
화학적 성질
white powder
용도
A metabolite of Phenmetrazine.
Safety Profile
A human poison by ingestion. Poison experimentally by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by an unspecified route. Human systemic effects by ingestion: sleep, increased pulse rate without blood pressure decrease, and chronic pulmonary edema or congestion, convulsions, headache, and blood pressure elevation. Used in production of drugs of abuse. When heated to decomposition it emits toxic fumes of NOx.
참고 문헌
Kanao., Ber., 63,95 (1930) Wolfes., Arch. Pharrn., 268,87 (1930) Hey., J. Chern. Soc., 1232 (1930) Akabori, Momotani., J. Chern. Soc., Japan, 64, 608 (1943) Hoover, Hass., J. Org. Chern., 12,506 (1947)

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