SB 203580

한글명:SB 203580

카스 번호152121-47-6

상품명:SB 203580

CBNumberCB1680333

분자식C21H16FN3OS

포뮬러 무게377.43

MOL 파일152121-47-6.mol

화학적 성질

녹는점	144-146
끓는 점	615.6±55.0 °C(Predicted)
밀도	1.4
저장 조건	-20°C
용해도	DMSO: 50mg/mL
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	9.60±0.10(Predicted)
색상	흰색에서 황백색까지
안정성	-20℃에서 안정
InChIKey	CDMGBJANTYXAIV-UHFFFAOYSA-N
CAS 데이터베이스	152121-47-6(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

22-41

안전지침서

26-39

WGK 독일

HS 번호

29333990

NFPA 704:

	0
3		0

그림문자(GHS)

SB 203580 화학적 특성, 용도, 생산

화학적 성질
White to Off-White Solid
용도
MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.¹⁶ It was used to inhibit MAPK signaling in mouse cortical neurons¹⁷ and human hepatocellular carcinoma cell lines.¹⁸
정의
ChEBI: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
일반 설명
Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells). Also known as reactivating kinase (RK) and CSBP (cytokine synthesis anti-inflammatory drug binding protein). Does not significantly inhibit JNK or p42 MAP kinase even at 100 μM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC₅₀ = 50-100 nM). SB 203580 has also been shown to be an effective inhibitor of inflammatory cytokine production in vivo in both mice and rats.
생물학적 활성
Water-soluble salt of SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine ). Selective inhibitor of p38 mitogen-activated protein kinase (IC 50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 β and PKB α . Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

SB 203580 공급 업체

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