신코카인

한글명:신코카인

카스 번호85-79-0

상품명:Cinchocaine

CBNumberCB1396856

분자식C20H29N3O2

포뮬러 무게343.46

MOL 파일85-79-0.mol

동의어(한글)

디부카인

신코카인

신코카인및그염류

화학적 성질

녹는점	64°
끓는 점	478.73°C (rough estimate)
밀도	1.1145 (rough estimate)
굴절률	1.6300 (estimate)
저장 조건	Store at -20°C
용해도	DMSO:45.0(Max Conc. mg/mL);131.02(Max Conc. mM)
산도 계수 (pKa)	pKa -5.3(aq. H2SO4) (Uncertain)
물리적 상태	Solid:particulate/powder
색상	White to yellow
수용성	68.01mg/L(온도는 명시되지 않음)
InChI	InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)
InChIKey	PUFQVTATUTYEAL-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2)C(C(NCCN(CC)CC)=O)=CC=1OCCCC
LogP	4.4 at 25℃ and pH7
CAS 데이터베이스	85-79-0(CAS DataBase Reference)
NIST	Dibucaine(85-79-0)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

22-41

안전지침서

26-39

RTECS 번호

GD3150000

유해 물질 데이터

85-79-0(Hazardous Substances Data)

NFPA 704:

	0
3		0

그림문자(GHS)

신코카인 화학적 특성, 용도, 생산

용도
Cinchocaine is a local anesthesic,used for Na⁺channel blocker.
정의
ChEBI: A monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally o ly used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.
일반 설명
Articaine has a secondary nitrogen with a pKa of 7.8. It containsan aromatic thiophene ring bioisostere of the phenylring found in most other amide anesthetics. The log P of abenzene ring is 2.13 and the thiophene ring log P is 1.81,thus the thiophene ring is more hydrophilic than a phenylring. Although the thiophene ring has less lipid solubilitythan a phenyl ring, articaine is a lipid-soluble compound dueto the propylamine, the branched methyl and the substitutionson the thiophene ring. The onset of action of articaineis similar to lidocaine’s onset of action.
색상 색인 번호
Dibucaine hydrochloride is an amide group local anesthetic that can induce allergic contact dermatitis.
Clinical Use
Articaine is availablein a 4% solution with epinephrine for use in infiltrationand nerve block anesthesia.Articaine is metabolized rapidly via plasma and tissuecarboxyesterase to its primary metabolite, the inactive,water-soluble carboxylic acid. Approximately 40% to 70%of articaine administered epidurally is metabolized to thecarboxylic acid, articainic acid. Approximately 4% to 15%of the articainic acid undergoes glucuronide conjugationand only 3% of the dose is recovered unchanged in theurine. The rapid plasma metabolism and reported inactivityof the carboxylic acid metabolite make articaine a potentiallysafer anesthetic agent when multiple or large dosesare necessary.

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