N-말레오일-β-알라닌

한글명:N-말레오일-β-알라닌

카스 번호7423-55-4

상품명:3-Maleimidopropionic acid

CBNumberCB1371466

분자식C7H7NO4

포뮬러 무게169.13

MOL 파일7423-55-4.mol

동의어(한글)

N-말레오일-β-알라닌

화학적 성질

녹는점	103-106 °C (lit.)
끓는 점	382.5±25.0 °C(Predicted)
밀도	1.473±0.06 g/cm3(Predicted)
저장 조건	2-8°C
용해도	DMSO(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)	4.18±0.10(Predicted)
물리적 상태	고체
물리적 상태	단단한 모양
색상	하얀색
수용성	메탄올, 디메틸 포름아미드, 알코올 및 디메틸 설폭사이드에 용해됩니다. 물에 약간 용해됩니다.
감도	Moisture Sensitive
BRN	1528952
InChIKey	IUTPJBLLJJNPAJ-UHFFFAOYSA-N
CAS 데이터베이스	7423-55-4(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

26-36

WGK 독일

F 고인화성물질

10-21

HS 번호

29252900

NFPA 704:

	0
2		0

그림문자(GHS)

N-말레오일-β-알라닌 화학적 특성, 용도, 생산

화학적 성질
White to Pale Yellow Solid
용도
3-Maleimidopropionic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent.
주요 응용
3-Maleimidopropionic acid (3MP) is a molecule that can be used for the treatment of cancer. 3MP has been shown to inhibit the growth of tumor cells and induce apoptosis. It also inhibits the production of reactive oxygen species, which are produced by cancer cells as a result of chemotherapy. 3MP has potent inhibitory activity against bacterial organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens and antiviral properties against HIV infection. This molecule can also be used in conjunction with monoclonal antibodies or other immunotherapy techniques to improve their efficacy.
일반 설명
N-Maleoyl-β-alanine (3-maleimidopropanoic acid) is an aliphatic N-substituted maleimide. It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.
Synthesis
An acetic acid solution of maleic anhydride (5.00 g in 50 mL) was added dropwise to an acetic acid solution of β-alanine (4.54 g in 50 mL). The mixture was stirred at room temperature. After 3 h, AcOH (70 mL ) was added and the temperature was raised to 115 °C under stirred overnight. After 1 hour, an orange oil was obtained. The solvent excess was removed under reduced pressure and the product was washed with toluene (3 × 30 mL). The product was then purified by flash chromatography using a silica column (DCM/ethylacetate 9:1) to obtain the white solid 3-Maleimidopropionic acid.

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