안데노신 5''-트리인산염 디나트륨 염

한글명:안데노신 5''-트리인산염 디나트륨 염

카스 번호987-65-5

상품명:ATP disodium salt

CBNumberCB1360204

분자식C10H17N5NaO13P3

포뮬러 무게531.18

MOL 파일987-65-5.mol

동의어(한글)

안데노신5''-트리인산염디나트륨염

안데노신5'-트리인산염디나트륨염

안데노신5'-트리인산염디나트륨염(ADENOSINE5'-TRIPHOSPHATEDISODIUMSALT...

화학적 성질

녹는점	188～190℃
밀도	1.85 at 20℃
증기압	0.1Pa at 20-50℃
저장 조건	-20°C
용해도	H₂O: 50 mg/mL
물리적 상태	수정 같은
색상	백색분말
pH 범위	2.5 - 3.5
수용성	물에 용해됨
Merck	155
InChIKey	TTWYZDPBDWHJOR-IDIVVRGQSA-L
LogP	-2.66 at 24℃ and pH7
표면장력	67.86mN/m at 1.019g/L and 20℃
CAS 데이터베이스	987-65-5(CAS DataBase Reference)
EPA	Adenosine 5'-(tetrahydrogen triphosphate), disodium salt (987-65-5)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	22-24/25-36-26
WGK 독일	3
RTECS 번호	AU7417000
F 고인화성물질	10-21
HS 번호	29389090

그림문자(GHS)

안데노신 5''-트리인산염 디나트륨 염 MSDS

안데노신 5''-트리인산염 디나트륨 염 화학적 특성, 용도, 생산

개요
ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is an organic sodium salt. It consists of an ATP and a ({(2R,3S,4R,5R)-3,4-dihydroxy-5-(9h -purin-9-yl)oxolan-2-yl)methylphosphonatooxy)phosphonate. It has the role of providing a source of energy for cells and is a central component of energy storage and metabolism in the body. ATP disodium salt is an important endogenous signalling molecule in immunity and inflammation. It is an important component in the study of various physiological and biochemical processes. It is involved in a variety of cellular functions such as muscle contraction, nerve impulse transmission and membrane transport, making it a fundamental molecule for understanding biological mechanisms. It can also be used to photometrically determine Luc activity in cell extracts.
화학적 성질
White powder
용도
A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism. ATP Disodium Salt is used in the synthetic preparation of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands.
생물학적 활성
P2 purinoceptor agonist.
in vitro
ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on activating the NLRP3 inflammasome in HGFs.
ATP disodium salt (2 mM; 0.5-24 hours) induces the secretion of interleukin 1β, KC, and MIP-2 from bone marrow-derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.
ATP disodium salt stimulates cytokine and chemokine secretion, and inflammasome activation, directly and indirectly, induces in vitro neutrophil chemotaxis.
Toxicity evaluation
ATP disodium salt was administered by gavage to rats for 90 consecutive days at doses of 0 (control), 500, 1000, and 2000 mg kg BW?1·d?1 (n = 10 per sex/group). Subchronic administration of ATP was well tolerated at all dose levels. Body weights and feed consumption body weight gains were similar between ATP-treated and control rats. Minor differences were seen in hematology and blood chemistry; however, these changes were not dose-related and, therefore, not of biological or toxicological significance. Only one difference was observed in absolute organ weights; females of the high dose had increased kidney and increased relative kidney and liver weights; however, these differences were not seen in males nor appeared to be dose-related[1].

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