아세토헥사마이드

한글명:아세토헥사마이드

카스 번호968-81-0

상품명:ACETOHEXAMIDE

CBNumberCB1316029

분자식C15H20N2O4S

포뮬러 무게324.4

MOL 파일968-81-0.mol

동의어(한글)

아세토헥사마이드

화학적 성질

녹는점	188-190° (GB 912789); mp 175-177° (Marshall)
밀도	1.2528 (rough estimate)
굴절률	1.6930 (estimate)
저장 조건	Refrigerator
용해도	DMSO: ~45 mg/mL
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	4.32±0.10(Predicted)
색상	하얀색
수용성	0.25g/L(25℃)
CAS 데이터베이스	968-81-0
EPA	Acetohexamide (968-81-0)

위험 및 안전 성명

안전지침서	36
WGK 독일	2
RTECS 번호	YR7350000
유해 물질 데이터	968-81-0(Hazardous Substances Data)
독성	LD50 oral in rat: > 2gm/kg

아세토헥사마이드 화학적 특성, 용도, 생산

용도
Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.
정의
ChEBI: An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a p-acetylphenylsulfonyl group, while a hydrogen attached to the other nitrogen is replaced by a cyclohexyl group.
일반 설명
Acetohexamide is 4-acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide; or 1-[(p-acetylphenyl)sulfonyl]-3-cyclohexylurea; or 1-(p-acetylbenzenesulfonyl)-3-cyclohexylurea(generic). Acetohexamide incorporates the nearly optimal(for potency) cyclohexyl moiety in the “right-hand” sideof its molecular structure, but a p-acetyl substituent on the“left-side” benzene ring that decreases lipophilicity and israpidly biotransformed by reduction to an active metabolitethat is cleared relatively rapidly (see preceding discussion) independentlyof any P450s.
공기와 물의 반응
Water insoluble.
반응 프로필
An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
화재위험
Flash point data for ACETOHEXAMIDE are not available; however, ACETOHEXAMIDE is probably combustible.
Clinical Use
Acetohexamide is metabolized in the liver to a reducedform, the α -hydroxyethyl derivative. This metabolite, themain one in humans, possesses hypoglycemic activity.Acetohexamide is intermediate between tolbutamide andchlorpropamide in potency and duration of effect on bloodsugar levels.
Safety Profile
Human reproductive effects by an unspecified route: stillbirth. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of SO, and NOx,.

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