오로트산마그네슘

한글명:오로트산마그네슘

카스 번호34717-03-8

상품명:Magnesium Orotate

CBNumberCB1257706

분자식C10H4MgN4O8

포뮬러 무게332.47

MOL 파일34717-03-8.mol

동의어(한글)

오로트산마그네슘

화학적 성질

저장 조건	-20°C
InChI	InChI=1S/2C5H4N2O4.Mg/c28-3-1-2(4(9)10)6-5(11)7-3;/h21H,(H3,6,7,8,9,10,11);/q;;+4/p-4
InChIKey	MEZKYWVZYGZEHX-UHFFFAOYSA-J
SMILES	O=C1NC(=O)C=C2C(=O)[O-][Mg+2]3([O-]C(=O)C4=CC(=O)NC(=O)N34)N12
LogP	-0.928 (est)
EPA	Magnesium, bis(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylato-.kappa.N3,.kappa.O4)-, (T-4)- (34717-03-8)

위험 및 안전 성명

위험 등급

IRRITANT

오로트산마그네슘 화학적 특성, 용도, 생산

마그네슘(magnesium) 보충제의
오로트산마그네슘은 쉽게 흡수되고 강한 하제 효과를 가지고 있지 않습니다 .
초기 연구에 따르면 오로트산이 심장과 혈관 조직의 에너지 생산 경로에 독특한 역할을 함에 따라 심장 건강을 증진시킬 수 있다고 합니다.
그렇기 때문에, 오로트산마그네슘은 운동 선수들과 운동 애호가들 사이에서 인기가 있지만, 심장병을 가진 사람들에게도 도움이 될 수 있습니다.
심각한 울혈성 심부전 환자 79명을 대상으로 한 한 연구에서 오로트산마그네슘이 위약보다 증상 관리와 생존에 훨씬 더 효과적이라는 것이 밝혀졌습니다.
하지만, 이 형태는 다른 마그네슘 보충제보다 비싸다는 단점이 있습니다.
개요
Magnesium orotate is a magnesium salt of orotic acid and is poorly soluble in water. It is a source of magnesium and is used as a mineral supplement to treat Mg deficiency. Orotic acid acts as a transporter that carries magnesium into the cells. It also exhibits antioxidant properties, since it is a key intermediate in the biosynthetic pathway of pyrimidines that promotes the synthesis of enzymes which act as free radical scavengers. Experiments investigating the potential cardioprotective actions of orotic acid in pathological heart conditions are still ongoing.
용도
magnesium orotate is used as an adjuvant treatment in congestive heart failure, hyperten-sion, post-operative cardiac status or in type 2 diabetes.
Magnesium orotate combines in itself the cardio protective properties of magnesium and orotic acid and leads to the optimisation of the magnesium effect by reducing cellular magnesium loss.
At the same time, animal studies have indicated a protective effect of magnesium orotate with respect to atherosclerotic vascular changes. The efficacy of the combination was superior to the effect of the individual components of magnesium and orotic acid.
제조 방법
For the synthesis of magnesium orotate and due to the low solubility of both magnesium hydroxide and orotic acid, 50 mL H2O were heated up to 70 °C. Half of the magnesium hydroxide (total: 0.125 g, 2.16 mmol, 1 eq.) was added to the warm solution. Subsequently, small amounts of both orotic acid (total: 0.75 g, 4.31 mmol, 2 eq.) and the remaining magnesium hydroxide were added alternatingly. After heating the solution to 90 °C and stirring it for 30 min, it was stored in the fridge for crystallization. After one weekend, 0.70 g (1.46 mmol, 68 %) of a white microcrystalline material could be obtained after filtration and drying.

IR, NMR and PXRD analysis (presented in sections S2 and S4) confirmed the product to be magnesium orotate octahydrate.

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