Tobramycin sulfate

한글명:Tobramycin sulfate

카스 번호49842-07-1

상품명:Tobramycin sulfate

CBNumberCB0475411

분자식C18H39N5O13S

포뮬러 무게565.59

MOL 파일49842-07-1.mol

화학적 성질

저장 조건	2-8°C
용해도	메탄올(약간), 물(적당)에 용해됨
물리적 상태	가루
색상	White to off-white
수용성	물에 용해됩니다(50mg/ml).
안정성	흡습성
CAS 데이터베이스	49842-07-1
EPA	Tobramycin sulfate (49842-07-1)

위험 및 안전 성명

위험품 표기	T
위험 카페고리 넘버	61-20/21/22
안전지침서	53-22-36/37/39-45
WGK 독일	3
HS 번호	2941900000

그림문자(GHS)

Tobramycin sulfate 화학적 특성, 용도, 생산

용도
Tobramycin sulfate is used as an antibiotic which is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections1. Product T1783 has been used to study antibiotic resistance2.
Clinical Use
Introduced in 1976, tobramycin sulfate (Nebcin) is the mostactive of the chemically related aminoglycosides called nebramycinsobtained from a strain of Streptomyces tenebrarius Five members of the nebramycin complex have beenidentified chemically.
Factors 4 and 4＇ are 6＂-O-carbamoylkanamycin B andkanamycin B, respectively; factors 5＇ and 6 are 6＂-O-carbamoyltobramycinand tobramycin; and factor 2 isapramycin, a tetracyclic aminoglycoside with an unusual bicycliccentral ring structure. Kanamycin B and tobramycinprobably do not occur in fermentation broths per se but areformed by hydrolysis of the 6-O＂-carbamoyl derivatives inthe isolation procedure.
The most important property of tobramycin is its activityagainst most strains of P. aeruginosa, exceeding that of gentamicinby twofold to fourfold. Some gentamicin-resistantstrains of this troublesome organism are sensitive to tobramycin,but others are resistant to both antibiotics. OtherGram-negative bacilli and staphylococci are generally moresensitive to gentamicin. Tobramycin more closely resembleskanamycin B in structure (it is 3＇-deoxykanamycin B).

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