6-히드록시도파민 염화수소산염

한글명:6-히드록시도파민 염화수소산염

카스 번호28094-15-7

상품명:6-HYDROXYDOPAMINE HYDROCHLORIDE

CBNumberCB0320270

분자식C8H12ClNO3

포뮬러 무게205.64

MOL 파일28094-15-7.mol

동의어(한글)

6-히드록시도파민염화수소산염

6-하이드록시도파민염산염

화학적 성질

녹는점	232-233 °C (dec.)(lit.)
저장 조건	room temp
용해도	H₂O: >50 mg/mL, 투명, 노란색~갈색
물리적 상태	가루
색상	황백색에서 갈색까지
BRN	4274007
InChI	InChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChIKey	QLMRJHFAGVFUAC-UHFFFAOYSA-N
SMILES	C1(CCN)=CC(=C(O)C=C1O)O.Cl
EPA	6-Hydroxydopamine hydrochloride (28094-15-7)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
WGK 독일	3
RTECS 번호	DC4650000
F 고인화성물질	3-8-10-23

그림문자(GHS)

6-히드록시도파민 염화수소산염 화학적 특성, 용도, 생산

개요
6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.
용도
6-hydroxydopamine hydrochloride has been used:
- to induce Parkinson′s disease (PD) in rats
- to analyse cytotoxic effect of 6-OHDA on PC12 cell line
- to induce noradrenergic (NA) neuron deletion from the locus-coeruleus
일반 설명
Beige solid.
공기와 물의 반응
Hygroscopic. Water soluble.
반응 프로필
A weak acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
건강위험
ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-HYDROXYDOPAMINE HYDROCHLORIDE emits very toxic fumes.
화재위험
Flash point data for 6-HYDROXYDOPAMINE HYDROCHLORIDE are not available. 6-HYDROXYDOPAMINE HYDROCHLORIDE is probably combustible.
생물학적 활성
Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

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