알파-D-락토제 모노수화물

알파-D-락토제 모노수화물 화학적 특성, 용도, 생산

• 화학적 성질

  White powder

• 용도

  alpha-D-Lactose monohydrate is used as a carrier and stabiliser of aromas, pharmaceutical products, Food industry.

• 정의

  A sugar that occurs in many plants. It is extracted commercially from sugar cane and sugar beet. Sucrose is a disaccharide formed from a glucose unit and a fructose unit. It is hydrolyzed to a mixture of fructose and glucose by the enzyme invertase. Since this mixture has a different optical rotation (levorotatory) than the original sucrose, the mixture is called invert sugar.

• 생산 방법

  A suspension of a-lactose monohydrate crystals in a lactose solution is atomized and dried in a spray drier. Approximately 10–20% of the total amount of lactose is in solution and the remaining 80–90% is present in the crystalline form. The spray-drying process predominantly produces spherical particles. The compactibility of the material and its flow characteristics are a function of the primary particle size of the lactose monohydrate and the amount of amorphous lactose.

• Pharmaceutical Applications

  Spray-dried lactose is widely used as a binder, filler-binder, and flow aid in direct compression tableting.

• Safety

  Lactose is widely used in pharmaceutical formulations as a diluent in oral capsule and tablet formulations. It may also be used in intravenous injections.
  Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the enzyme lactase.

• 저장

  Spray-dried lactose should be stored in a well-closed container in a cool, dry place.

• 비 호환성

  Lactose is a reducing sugar. The amorphous lactose, which is the most reactive form of lactose present in spray-dried lactose, will interact more readily than conventional crystalline grades. Typical reactions include the Maillard reaction with either primary or secondary amines.

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