6-アミノ-3-メチル-1-(2-メチル-2-プロペニル)ピリミジン-2,4(1H,3H)-ジオン

6-アミノ-3-メチル-1-(2-メチル-2-プロペニル)ピリミジン-2,4(1H,3H)-ジオン 化学特性,用途語,生産方法

• Originator

  Rolicton,Searle,US,1956

• Manufacturing Process

  Preparation of the ethyl analog is as follows (methyl isocyanate is used in amisometradine manufacture).
  To a cooled and stirred solution of 142 parts of methallylamine in 900 parts of benzene, 156 parts of ethyl isocyanate are added dropwise. Upon concentration in vacuum N-ethyl-N'-methallylurea is obtained.
  260 parts of this urea derivative are dissolved in 500 parts of acetic anhydride and treated with 157 parts of cyanoacetic acid at 60°C and heated at that temperature for 2 hours. The solution is then concentrated in vacuum to a syrup. 100 parts of water are added and the vacuum distillation is repeated. The remaining syrup contains a mixture of N-cyanoacetyl-N-ethyl-N'- methallylurea and a small quantity of N-cyanoacetyl-N-methallyl-N'-ethylurea.
  This syrup is treated with sufficient 20% sodium hydroxide solution to raise the pH to 10. A violent reaction occurs. The reaction mixture is diluted with 50 parts of water, stirred, cooled and filtered. The material collected on the filter is recrystallized from 10% ethanol to yield a mixture of 1-methallyl-3-ethyl-6- amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione and 1-ethyl-3-methallyl-6- amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione melting at about 157-159°C.

• Therapeutic Function

  Diuretic

6-アミノ-3-メチル-1-(2-メチル-2-プロペニル)ピリミジン-2,4(1H,3H)-ジオン 上流と下流の製品情報

6-アミノ-3-メチル-1-(2-メチル-2-プロペニル)ピリミジン-2,4(1H,3H)-ジオン 生産企業

Global(14)Suppliers

550-28-7, 6-アミノ-3-メチル-1-(2-メチル-2-プロペニル)ピリミジン-2,4(1H,3H)-ジオン キーワード