よう化トリジヘキセチル

よう化トリジヘキセチル 化学特性,用途語,生産方法

• Originator

  Pathilon,Burroughs-Wellcome,US,1955

• Manufacturing Process

  Acetophenone, paraformaldehyde and diethylamine are first reacted to give ω- diethylaminopropiophenone. That is reacted with cyclohexylmagnesium bromide to give 3-diethylamino-1-cyclohexyl-1-phenylpropanol-1. To 1,320 parts of methyl isobutyl ketone is added 570 parts of 3- diethylamino-1-cyclohexyl-1-phenylpropanol-1 (2 mols) and the mixture is stirred until solution is complete. Then 500 parts (3.2 molsor 60% excess) of ethyl iodide are added. After filtration, the filtrate is diluted with an additional 300 parts of methyl isobutyl ketone and the solution is then heated at the reflux temperature (108°C to 110°C) for 9 hours. After cooling to 0°C, the precipitated solid material is removed by filtration, washed with isopropyl acetate and dried. Approximately 777 parts of product is obtained or a yield of 88.6% based on as-is starting material or 92.5% based on real starting material.

• Therapeutic Function

  Anticholinergic

よう化トリジヘキセチル 上流と下流の製品情報

よう化トリジヘキセチル 生産企業

Global(2)Suppliers

125-99-5, よう化トリジヘキセチル キーワード