クロロ酢酸メチル

化学名:クロロ酢酸メチル

CAS番号.96-34-4

英語名:Methyl chloroacetate

CBNumberCB9854725

MFC3H5ClO2

MW108.52

MOL File96-34-4.mol

别名

クロロ酢酸メチル

メチルクロロアセタート

2-クロロ-1-メトキシエタノン

クロロ酢酸メチル物理性質

融点	-33 °C
沸点	130 °C740 mm Hg(lit.)
比重(密度)	1.238 g/mL at 25 °C(lit.)
蒸気密度	3.8 (vs air)
蒸気圧	10 mm Hg ( 25 °C)
屈折率	n20/D 1.422(lit.)
闪点	125 °F
貯蔵温度	Store at <= 20°C.
溶解性	51.6g/l（遅分解）
外見	液体
色	無色透明
PH	4.6 (28g/l, H2O, 20℃)
爆発限界(explosive limit)	4.6-18.5%(V)
水溶解度	28g/L（20℃）
Merck	14,6042
BRN	506255
Dielectric constant	12.9（20℃）
LogP	0.63 at 20℃
CAS データベース	96-34-4(CAS DataBase Reference)
NISTの化学物質情報	Acetic acid, chloro-, methyl ester(96-34-4)
EPAの化学物質情報	Acetic acid, 2-chloro-, methyl ester (96-34-4)

安全性情報

主な危険性	T,Xi,F
Rフレーズ	10-23/25-37/38-41-40-36/37/38-38
Sフレーズ	26-37/39-45-36-16
RIDADR	UN 2295 6.1/PG 1
WGK Germany	2
RTECS 番号	AF9500000
F	19
自然発火温度	869 °F
TSCA	Yes
HSコード	2915 40 00
国連危険物分類	6.1
容器等級	I
有毒物質データの	96-34-4(Hazardous Substances Data)
毒性	LD50 orally in Rabbit: 107 mg/kg
消防法	危-4-2-III
化審法	(2)-1149
毒劇物取締法	毒物

危険有害性情報のコード(GHS)

クロロ酢酸メチル価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01ACSM-552-R-04	1mL	￥13400	メチル=クロロアセタート	購入
富士フイルム和光純薬株式会社(wako) W01ACSM-552.2-05	1mL	￥8900	メチル=クロロアセタート	購入
東京化成工業 C0093	25mL	￥2000	クロロ酢酸メチル >98.0%(GC)	購入
東京化成工業 C0093	500mL	￥4000	クロロ酢酸メチル >98.0%(GC)	購入
関東化学株式会社(KANTO) 25226-00	500mL	￥6300	クロロ酢酸メチル >97.0%(GC)	購入

クロロ酢酸メチル化学特性,用途語,生産方法

外観
無色～わずかにうすい褐色, 澄明の液体
溶解性
水に微溶 (46g/L), エタノール, エーテルに混和。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。
化学的特性
clear colorless liquid with a slight irritating odor. It is miscible with organic solvents such as ethanol, ether, acetone and benzene. Slightly soluble in water.
使用
Methyl chloroacetate is used as a solvent and chemical intermediate. It acts as a precursor in the preparation of (carboxymethyl) trimethylammonium chloride esters. Further, it is used in the preparation of octakis-(carbethoxymethoxy)calix[8]arene. It is employed as an extraction solvent during the separation of neutral compounds. In addition to this, it is used in the synthesis of dimethyl carbonate.
主な応用
Methyl chloroacetate (MC) is a halogenated ester mainly used as a solvent in organic synthesis or in the preparation of several compounds. Typically, MC is used in the preparation of (carboxymethyl) trimethylammonium chloride estersor in the synthesis of octakis- (carbethoxymethoxy)calix[8]arene. Additionally, methyl chloroacetate acts as an extraction solvent during the separation of neutral compounds with concentration enhancement using coupling liquid–liquid semi-microextraction with micellar electrokinetic chromatography through oncapillary decomposition.
製造方法
Methyl chloroacetate is prepared by esterification of chloroacetic acid with methanol.
Reaction: Methanol and chloroacetic acid are uniformly mixed in a weight ratio of 0.366:1, heated with stirring, and the esterification reaction is carried out at 105-110 °C. In the reaction process, the ternary azeotrope of methyl chloroacetate, water and methanol is continuously steamed, layered through the ester separator, the separated methanol and water are returned to the reaction pot, and the separated crude ester is made of sodium carbonate. neutralize. The neutralized crude ester is firstly cut out the 130°C fraction by atmospheric distillation, and then subjected to vacuum distillation to collect the 65°C (8kPa) fraction, which is the finished product of methyl chloroacetate. The yield is about 96%.
一般的な説明
A crystalline solid or a solid dissolved in a liquid. Insoluble in water and denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals.
空気と水の反応
Highly flammable. Insoluble in water.
反応プロフィール
Methyl chloroacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
危険性
Toxic by ingestion and inhalation.
健康ハザード
Extremely corrosive to the eyes, skin, nose, throat, and upper respiratory tract. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
火災危険
Special Hazards of Combustion Products: Toxic fumes of hydrogen chloride
安全性プロファイル
Poison by ingestion. Moderately toxic by inhalation and subcutaneous routes. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Cl-.
純化方法
Shake the ester with saturated aqueous Na2CO3 (three times), aqueous 50% CaCl2 (three times), saturated aqueous NaCl (twice), dry (Na2SO4) and fractionally distil it. Very toxic. [Beilstein 2 IV 480.]

クロロ酢酸メチル上流と下流の製品情報

クロロ酢酸メチル生産企業

クロロ酢酸メチルスペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

96-34-4, クロロ酢酸メチルキーワード

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クロロ酢酸メチル

危険有害性情報のコード(GHS)

クロロ酢酸メチル 価格

クロロ酢酸メチル 化学特性,用途語,生産方法

クロロ酢酸メチル 上流と下流の製品情報

クロロ酢酸メチル 生産企業

クロロ酢酸メチル スペクトルデータ(1HNMR、13CNMR、IR1、IR2、MS、Raman)

96-34-4, クロロ酢酸メチル キーワード

クロロ酢酸メチル価格

クロロ酢酸メチル化学特性,用途語,生産方法

クロロ酢酸メチル上流と下流の製品情報

クロロ酢酸メチル生産企業

クロロ酢酸メチルスペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

96-34-4, クロロ酢酸メチルキーワード