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MSDS Information

• 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-beta-methoxy-alpha,gamma,2,8-tetramethyl-1,6-dioxaspiro[4.5]decane-7-butyric acid

モネンシン 化学特性,用途語,生産方法

• 解説

  C36H62O11(670.89)．放線菌Streptomyces cinnamonensisの産生するポリエーテル抗生物質．"融点103～105 ℃(一水和物)．[α]_D＋47.4°．pKa 6.6．有機溶媒に易溶，水に微溶．イオノホア抗生物質で，一価金属と包接化合物をつくり，それらのイオンを細胞膜透過性にする．親和性はNa⁺ ≥ K＋ ＞ Rb＋とされている．抗菌，抗真菌，抗原虫作用がある．ナトリウム塩は融点267～269 ℃．家畜の飼料添加剤に用いられる．LD50 43.8±5.2 mg/kg(マウス，経口)．[CAS 17090-79-8][CAS 22373-78-0:Na塩]
  森北出版「化学辞典（第2版）

• 効能

  抗生物質, 抗真菌薬, 抗原虫薬

• 説明

  Monensin was found in the mycelium of Streptomyces cinnamonensis by Eli Lilly & Co. in 1967 in the course of screening for anticoccidial and growth-promoting substances for cattle, swine, and chickens. It shows antiprotozoal, antibacterial, and antifungal activities, as well as anticoccidial activity. Monensin is widely used to treat such infections and as a feed additive to promote the growth of livestock.

• 化学的特性

  Crystallin Solid

• 使用

  Monensin A is a polyether antibiotic first isolated from Streptomyces cinnamonensis in 1967. Monensin A is a broad-spectrum anticoccicidial antibiotic, also exhibiting antifungal and antiviral activity. Monensin A forms complexes with monovalent cations such as Li+, Na+, K+, Rb+, Ag+ and Tl+ and is thus able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport and is used in animals to prevent coccidiosis, promote growth and prevent bloat. Derivatives of monensin, monensin methyl ester and particularly monensin decyl ester, are used in ion selective electrodes.

• 安全性プロファイル

  Poison by ingestion and intraperitoneal routes. An eye and skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

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17090-79-8, モネンシン キーワード