トシル酸インプロスルファン

トシル酸インプロスルファン 化学特性,用途語,生産方法

• 効能

  抗悪性腫瘍薬, アルキル化剤

• Originator

  Protecton,Yoshitomi,Japan,1980

• Manufacturing Process

  A solution of 5 g of bis(3-methylsulfonyloxypropyl)amine hydrochloride in 20 ml of ice water is neutralized with 1N sodium carbonate solution. The resulting amine base is extracted with five 20 ml portions of chloroform. The combined extract is dried over anhydrous sodium sulfate, the solvent is distilled off under reduced pressure, and the residue is dissolved in 20 ml of ethanol. To the ethanol solution is added slowly with stirring under ice cooling a solution of 2.6 g of p-toluenesulfonic acid in 30 ml of ethanol. The white precipitate formed is collected by filtration and recrystallized from ethanol to give 5.0 g of white crystalline bis(3-methylsulfonyloxypropyl)amine p-toluenesulfonate melting at 115°C to 116°C.

• Therapeutic Function

  Antitumor

トシル酸インプロスルファン 上流と下流の製品情報

トシル酸インプロスルファン 生産企業

Global(1)Suppliers

32784-82-0, トシル酸インプロスルファン キーワード