ジメタクリン

ジメタクリン 化学特性,用途語,生産方法

• 効能

  抗うつ薬, アセチルコリンエステラーゼ阻害薬

• Originator

  Isotonil,Siegfried,W. Germany,1967

• Manufacturing Process

  A mixture of 10.0 g of 5.5-dimethylacridan, 2.0 g of pulverized sodium amide and 6.5 g of 1-chloro-3-dimethylaminopropane in 50 ml of xylene is heated at reflux with stirring for one hour. To the cooled reaction mixture is added one volume of water. The organic layer is separated and extracted several times with diluted lactic acid. The acidic extracts are combined, washed with ether and neutralized by alkali. The crude 10-(3'-dimethylaminopropyl)-5,5- dimethylacridan is isolated by ether extraction and purified by distillation in a high vacuum. The yield is 6.4 g BP 170°-180°C/0.005mm. nD29 = 1.5990.
  43 g of the base I are dissolved in 229 ml of 1 N aqueous d-tartaric acid and the clear solution so obtained is evaporated to dryness under reduced pressure. The residue is dissolved in 150 ml of 90% ethanol which solution after cooling gives the tartaric acid salt of I in white needles. The salt contains 1 mol of tartaric acid per 1 mol of the base. MP 155°-156°C. Easily soluble in cold water.

• Therapeutic Function

  Antidepressant

ジメタクリン 上流と下流の製品情報

ジメタクリン 生産企業

Global(13)Suppliers

4757-55-5, ジメタクリン キーワード