トレチノイン トコフエリル

トレチノイン トコフエリル 化学特性,用途語,生産方法

• 効能

  皮膚潰瘍治療薬, レチノイン酸受容体(RAR)作動薬

• 商品名

  オルセノン (ポーラファルマ); オルセノン (ポーラファルマ)

• 説明

  Tretinoin tocoferil, the a-tocopherol ester of all-trans-retinoic acid, was launched for the treatment of bedsores and skin ulcers such as burn, leg, and diabetic ulcers. It is also an orally active agent for gastric ulcer treatment. Tretinoin tocoferil represents a new class of antiulcer drugs which act by directly promoting tissue repair, distinguished from common drugs that exert an indirect function by suppression of acid-secretion and mucosa protection. The mode of its action has been proposed to relate to its ability to stimulate DNA synthesis of growth-arrested human skin fibroblasts by promoting expression of the epidermal growth factor receptor.

• 使用

  dl-α-Tocopheryl Retinoate is an α-tocopherol ester of all-trans retinoic acid (R250200) and is safely used in the treatment of skin ulcer. ?dl-α-Tocopheryl Retinoate inhibited proliferation of human promyelocytic leukemia HL-60 cells and induced granulocytic differentiation of the cells, but to a lesser extent than did retinoic acid.

トレチノイン トコフエリル 生産企業

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