アルギン酸2-ヒドロキシプロピル

アルギン酸2-ヒドロキシプロピル 価格

アルギン酸2-ヒドロキシプロピル 化学特性,用途語,生産方法

• 外観

  白色〜うすい褐色, 粉末

• 定義

  本品は、アルギン酸(*)のプロピレングリコールエステルの混合物である。参照表示名称：アルギン酸

• 溶解性

  水に溶ける。粉末で冷水、熱水、酸性溶液に易溶。またカルシウム、金属塩などによって沈殿しない。低濃度でアルギン酸の特長である高い粘性を示す。

• 化粧品の成分用途

  結合剤、親水性増粘剤、香料

• 化学的特性

  Propylene glycol alginate occurs as a white to yellowish colored, practically odorless and tasteless, fibrous or granular powder.

• 使用

  Pharmaceutic aid (suspending agent); pharmaceutic aid (viscosity-increasing agent).

• 調製方法

  Alginic acid, extracted from brown seaweed, is reacted with propylene oxide to form propylene glycol alginate. Various grades may be obtained that differ in composition according to the degree of esterification and the percentage of free and neutralized carboxyl groups present in the molecule; complete esterification of alginic acid is impractical.

• 製造方法

  Derived from brown algae, also from alginic acid

• 応用例（製薬）

  Propylene glycol alginate is used as a stabilizing, suspending, gelling, and emulsifying agent in oral and topical pharmaceutical formulations. Typically, a concentration of 0.3–5% w/v is used, although this may vary depending upon the specific application and the grade of propylene glycol alginate used.
  Propylene glycol alginate is also used in cosmetics and food products.

• 安全性プロファイル

  Mddly toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.

• 安全性

  Propylene glycol alginate is used in oral and topical pharmaceutical formulations, cosmetics, and food products. It is generally regarded as a nontoxic and nonirritant material, although excessive oral consumption may be harmful. A study in five healthy male volunteers fed a daily intake of 175 mg/kg body-weight of propylene glycol alginate for 7 days, followed by a daily intake of 200 mg/kg body-weight of propylene glycol alginate for a further 16 days, showed no significant adverse effects.
  Inhalation of alginate dust may be irritant and has been associated with industrially related asthma in workers involved in alginate production. However, it appears that the cases of asthma were linked to exposure to seaweed dust rather than pure alginate dust.
  (hamster, oral): 7.0 g/kg
  (mouse, oral): 7.8 g/kg
  (rabbit, oral): 7.6 g/kg
  (rat, oral): 7.2 g/kg

• 貯蔵

  Propylene glycol alginate is a stable material, although it will gradually become less soluble if stored at elevated temperatures for extended periods.
  Propylene glycol alginate solutions are most stable at pH 3–6. In alkaline solutions, propylene glycol alginate is rapidly saponified. Alginate solutions are susceptible to microbial spoilage and should be sterilized or preserved with an antimicrobial preservative. However, sterilization processes may adversely affect the viscosity of propylene glycol alginate solutions; see Sodium Alginate.
  The bulk material should be stored in an airtight container in a cool, dry place.

• 規制状況(Regulatory Status)

  GRAS listed. Accepted in Europe for use as a food additive. Included in the FDA Inactive Ingredients Database (oral preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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