セフォテタンナトリウム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H317：アレルギー性皮膚反応を起こすおそれ

  H334：吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P284：呼吸用保護具を着用すること。

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

セフォテタンナトリウム 価格

セフォテタンナトリウム 化学特性,用途語,生産方法

• 効能

  抗生物質, 細胞壁合成阻害薬

• 説明

  Cefotetan disodium is a β-lactamase resistant, second generation cephalosporin with a serum half-life of about three hours, permitting twice-daily dosing.

• 使用

  Cefotetan Disodium is a related compound of Cefotetan (C242970), an antibiotic related to Cephalosporin that is used to treat bacterial infections.

• 定義

  ChEBI: The disodium salt of cefotetan.

• 臨床応用

  Cefotetan (Cefotan) is a third-generation cephalosporin thatis structurally similar to cefoxitin. Like cefoxitin, cefotetanis resistant to destruction by β-lactamases. It is also a competitiveinhibitor of many β-lactamases and causes transient inactivation of some of these enzymes. Cefotetan is reportedto synergize with β-lactamase–sensitive β-lactams but, unlikecefoxitin, does not appear to cause antagonism.
  The antibacterial spectrum of cefotetan closely resemblesthat of cefoxitin. It is, however, generally more activeagainst S. aureus, and members of the Enterobacteriaceaefamily sensitive to both agents. It also exhibits excellentpotency against H. influenzae and N. gonorrhoeae, includingβ-lactamase–producing strains. Cefotetan is slightly lessactive than cefoxitin against B. fragilis and other anaerobes.Enterobacter spp. are generally resistant to cefotetan, andthe drug is without effect against Pseudomonas spp.Cefotetan has a relatively long half-life of about 3.5hours. It is administered on a twice-daily dosing schedule. Itis excreted largely unchanged in the urine. Aqueoussolutions for parenteral administration maintain potency for24 hours at 25°C. Refrigerated solutions are stable for 4 days.
  Cefotetan contains the MTT group that has been associatedwith hypoprothrombinemia and alcohol intolerance.Another cephalosporin that lacks these properties should beselected for patients at risk for severe bleeding or alcoholism.

セフォテタンナトリウム 生産企業

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