3-(ヒドロキシニトロソアミノ)-L-アラニン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P330：口をすすぐこと。

  P501：内容物/容器を．．．に廃棄すること。

3-(ヒドロキシニトロソアミノ)-L-アラニン 化学特性,用途語,生産方法

• 化学的特性

  Crystalline Powder

• 使用

  Antibiotic substance from the fermentation of Streptomyces alanosinicus. The first natural product found to have a N-nitrosohydroxylamino group on an aliphatic chain. An experimental insect reproduction inhibitor

• 酵素阻害剤

  This antibiotic and aspartate/asparagine analogue (FW = 149.11 g/mol; CAS 5854-93-3), also named L-2-amino-3-(N-hydroxy-N-nitrosoamino) propionic acid, isolated from fermentation broths of Streptomyces alanosinicus, inhibits adenylosuccinate synthetase, disrupting de novo synthesis of AMP in both malignant and normal cells. That alanosine inhibits the adenylosuccinate synthetase reaction, the first step in the conversion of IMP to AMP, is evidenced by the accumulation of IMP, but not adenylosuccinate, in treated cells. L-Alanosine’s action is potentiated in methylthioadenosine phosphorylase (MTAP) deficiency. Clinical use is limited by its toxicity. At a concentration as low as 2.7 μM, L-alanosine completely inhibits the incorporation of hypoxanthine into adenosine triphosphate by cultured Novikoff rat hepatoma cells. A related agent, L-alanosyl-5-aminoimidazole-4-carboxylic acid ribonucleotide (or alanosyl-AICOR) has been synthesized enzymatically using 4-(N-succino)- 5-aminoimidazole-4-carboxamide ribonucleotide (or SAICAR) synthetase in conjunction with 5-aminoimidazole-4-carboxylic acid ribonucleotide and alanosine. Alanosyl-AICOR is not a substrate of adenylosuccinate lyase from rat skeletal muscle, but it was an apparent competitive inhibitor in both reactions catalyzed by the enzyme.

3-(ヒドロキシニトロソアミノ)-L-アラニン 上流と下流の製品情報

3-(ヒドロキシニトロソアミノ)-L-アラニン 生産企業

Global(40)Suppliers

5854-93-3, 3-(ヒドロキシニトロソアミノ)-L-アラニン キーワード