アンプロリウム塩酸塩 [生化学用]

化学名:アンプロリウム塩酸塩 [生化学用]

CAS番号.137-88-2

英語名:Amprolium Hydrochloride

CBNumberCB2101848

MFC14H20Cl2N4

MW315.24

别名

アンプロリウム標準品

アンプロリウム塩酸塩 [生化学用]

1-[(4-アミノ-2-プロピル-5-ピリミジニル)メチル]-2-メチルピリジニウムクロリド塩酸塩

アンプロリウム塩酸塩 [生化学用]物理性質

融点	239.0 to 243.0 °C
貯蔵温度	Inert atmosphere,Room Temperature
溶解性	メタノール（微量）、水（微量）
外見	粉
色	ホワイトからオフホワイト
BRN	4118699
InChI	InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1
InChIKey	PJBQYZZKGNOKNJ-UHFFFAOYSA-M
SMILES	C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.Cl.[Cl-]
CAS データベース	137-88-2(CAS DataBase Reference)
EPAの化学物質情報	Amprolium hydrochloride (137-88-2)

安全性情報

危険有害性情報のコード(GHS)

外観
白色〜うすい黄色, 結晶性粉末〜粉末
用途
高速液体クロマトグラフ法によるアンプロリウム定量用標準品。
効能
抗原虫薬, 抗コクシジウム薬 (獣医薬)
説明
Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (K_is = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing.
化学的特性
Crystalline powder
使用
Coccidiostatic;Thiamine transport inhibitor
定義
MeSH: Amprolium Hydrochloride is a veterinary coccidiostat that interferes with thiamine metabolism.
接触アレルゲン
Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.