AHU-377 (heMicalciuM salt)

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

  H400：水生生物に強い毒性

• 注意書き

  P273：環境への放出を避けること。

AHU-377 (heMicalciuM salt) 価格

AHU-377 (heMicalciuM salt) 化学特性,用途語,生産方法

• 使用

  Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

• Biochem/physiol Actions

  Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.

AHU-377 (heMicalciuM salt) 生産企業

Global(285)Suppliers

AHU-377 (heMicalciuM salt) スペクトルデータ(¹HNMR)

1369773-39-6, AHU-377 (heMicalciuM salt) キーワード