テジゾリドリン酸エステル

化学名:テジゾリドリン酸エステル

CAS番号.856867-55-5

英語名:Tedizolid Phosphate

CBNumberCB72676152

MFC17H16FN6O6P

MW450.32

MOL File856867-55-5.mol

别名

テジゾリドリン酸エステル

トレゾリドリン酸エステル

テジゾリドリン酸エステル (JAN)

テジゾリドリン酸エステル物理性質

融点	>235°C (dec.)
沸点	725.6±70.0 °C(Predicted)
比重(密度)	1.75±0.1 g/cm3(Predicted)
貯蔵温度	under inert gas (nitrogen or Argon) at 2-8°C
溶解性	DMSO (わずかに、超音波処理)
外見	個体
酸解離定数(Pka)	1.81±0.10(Predicted)
色	ホワイトからオフホワイト
安定性：	吸湿性

危険有害性情報のコード(GHS)

テジゾリドリン酸エステル化学特性,用途語,生産方法

効能
抗菌薬, タンパク質合成阻害薬
商品名
シベクトロ (バイエル薬品); シベクトロ (バイエル薬品)
説明
Tedizolid phosphate was approved by the US FDA in June 2014 for treatment of acute bacterial skin and skin structure infections caused by susceptible gram-positive pathogens, including MRSA. Tedizolid phosphate was discovered by Dong-A Pharmaceuticals in South Korea and developed in the USA by Cubist Pharmaceuticals (acquired from Trius Therapeutics in 2013, became a wholly owned subsidiary of Merck in 2015). The worldwide commercialization rights for tedizolid phosphate are divided between Cubist in the USA, Canada, and EU, and Bayer in Asia–Pacific, Latin America, and Africa. This second-generation oxazolidinone prodrug is rapidly converted to the active form tedizolid in the presence of endogenous phosphatases. It inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit of the ribosome, preventing formation of the 70S ribosomal initiation complex, and is 4-fold to 16-fold more potent against staphylococci and enterococci compared to linezolid. 251 With high oral bioavailability (approximately 90%) and long half-life (approximately 12 hours), tedizolid phosphate is the first oxazolidinone antibiotic which can be dosed once daily either orally or intravenously.
使用
Tedizolid, known as TR-700, is an oral and i.v administered intracellular antibacterial drug.
定義
ChEBI: A phosphate monoester resulting from the formal condensation of equimolar amounts of phosphoric acid with the hydroxy group of tedizolid . It is a prodrug of tedizolid, used for the treatment of acute bacterial skin infections caused by certain susceptibl bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.

テジゾリドリン酸エステル生産企業

856867-55-5, テジゾリドリン酸エステルキーワード

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テジゾリドリン酸エステル

危険有害性情報のコード(GHS)

テジゾリドリン酸エステル 化学特性,用途語,生産方法

テジゾリドリン酸エステル 生産企業

856867-55-5, テジゾリドリン酸エステル キーワード

テジゾリドリン酸エステル化学特性,用途語,生産方法

テジゾリドリン酸エステル生産企業

856867-55-5, テジゾリドリン酸エステルキーワード