BHC

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

  H312：皮膚に接触すると有害

  H351：発がんのおそれの疑い

  H362：授乳中の子に害を及ぼすおそれ

  H373：長期にわたる、または反復暴露により臓器の障 害のおそれ

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P263：妊娠中/授乳期中は接触を避けること。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

BHC 価格

BHC 化学特性,用途語,生産方法

• 解説

  1,2,3,4,5,6-ヘキサクロロシクロヘキサン略称BHC．ベンゼンヘキサクロリドともいう．紫外線またはアルカリの存在下で，ベンゼンに塩素を付加させてつくる．理論上8種類の異性体があり，すべて知られている．粗生成物の組成は，α 64％，β 10％，γ 13％，δ 9％，その他4％．一般に水に不溶，有機溶剤に可溶性の結晶で，蒸気は粘膜を刺激する．γ-およびα-異性体は殺虫力が強く，前者はとくに，ガメキサン(gammexan)とよばれる．融点は，α 158 ℃，β 312 ℃，γ 112.5 ℃，δ 138 ℃，ε 219 ℃，η 99 ℃．吸入すると頭痛，吐き気，下痢などの亜急性毒性，肝臓障害の慢性毒性を示す．農薬，衛生用殺虫剤として多量に使われたが，環境問題が生じて，現在は使用されていない．LD50 α 177，γ 91～190，δ 1000 mg/kg(ラット，経口).

• 化学的特性

  BHC is a white-to-brownish crystalline solid with a musty, phosgene-like odor.

• 使用

  Insecticide.

• 定義

  An environmentally persistent constituent of a wide variety of agricultural, medical, and veterinary products.

• 一般的な説明

  White to yellow powder or flakes. Musty odor. The gamma isomer is known as lindane, a systemic insecticide. Toxic by ingestion or inhalation.

• 反応プロフィール

  Halogenated aliphatic compounds, such as HEXACHLOROCYCLOHEXANE, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

• 危険性

  Highly toxic; questionable carcinogen.

• 職業ばく露

  The major commercial usage of BHC is based upon its insecticidal properties. α-BCH is used as an Agricultural chemical, pesticide, pharmaceutical, and veterinary drug. The 7-isomer has the highest acute toxic ity, but the other isomers are not without activity. It is gen erally advantageous to purify the 7-isomer from the less active isomers. The γ-isomer acts on the nervous system of insects, principally at the level of the nerve ganglia. As a result, lindane has been used against insects in a wide range of applications including treatment of animals, buildings, humans for ectoparasites, clothes; water for mosquitoes; living plants; seeds and soils. Some applications have been abandoned due to excessive residues, e.g., stored food stuffs. By voluntary action, the principal domestic producer of technical grade BHC requested cancellation of its BHC registrations on September 1, 1976. As of July 21, 1978, all registrants of pesticide products containing BHC voluntar ily canceled their registrations or switched their former BHC products to lindane formulations.

• 発がん性

  A bioassay of lindane of the NCI was published in 1977. The compound was administered for 80 weeks to groups of Osborne–Mendel rats and B6C3F1 mice. Time-weighted dietary levels for male rats were 236 or 472 ppm; for female rats, 135 or 270 ppm; and for male and female mice, 80 or 160 ppm. Results were as follows: in rats, no tumors occurred at a statistically significant incidence in the treated groups of either sex but (2) in mice, the incidence of hepatocellular carcinoma in lowdose males was significant when compared with that in the pooled controls (controls 5/49, low dose 19/49, p = 0.001). This finding, by itself, is insufficient to establish the carcinogenicity of lindane. The incidence of hepatocellular carcinoma in high-dose male mice was not significantly different from that in matched or pooled controls. It is concluded that under the conditions of this bioassay lindane was not carcinogenic for Osborne–Mendel rats or B6C3F1 mice.
  As with most other chlorinated insecticides, lindane has been shown to exhibit tumor promotional activity, possibly via inhibition of intercellular communication. Lindane exposures do inhibit formation of liver tumors following exposures to aflatoxin B1, suggesting an activity other than tumor promotion for lindane. Enhancement of enzymatic deactivation of aflatoxin via induction of microsomal enzymes may play a role in this phenomenon.
  The combination of lindane’s lack of significant mutagenic activity, its tumor promotional properties, and the lack of epidemiologic evidence suggest that lindane poses a minimal to nonexistent risk of cancer to humans under reasonable and prescribed use conditions.

• 輸送方法

  UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• 不和合性

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Decomposes on contact with powdered iron, aluminum, zinc, and on contact with strong bases producing trichlorobenzene.

• 廃棄物の処理

  A process has been developed for the destructive pyrolysis of benzene hexachloride @ 400 500℃ with a catalyst mixture which contains 5 10% of either cupric chloride, ferric chloride; zinc chloride; or aluminum chloride on activated carbon.

BHC 生産企業

Global(42)Suppliers

BHC スペクトルデータ(MS)

608-73-1, BHC キーワード