(+)-アフィディコリン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

(+)-アフィディコリン 価格

(+)-アフィディコリン 化学特性,用途語,生産方法

• 外観

  白色〜わずかにうすい黄色, 結晶性粉末〜粉末

• 溶解性

  メチルアルコール, DMSO,希薄な酸に可溶、水に難溶。

• 用途

  1.DNAポリメラーゼαおよびDNA合成に関する研究。2.同調培養試薬

• 効能

  再結 酢酸エチル

• 説明

  (+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels. Aphidicolin can be used, at 3 μM, to arrest cells in G₁/S phase or to increase gene amplification frequency.

• 化学的特性

  White crystal

• 使用

  (+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties.

• 定義

  ChEBI: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positi ns 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.

• 一般的な説明

  A cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.

• 参考文献

  W. Dalziel, et al., J. Chem. Soc., Perkin Trans. 1, 1973, 2841, DOI: 10.1039/p19730002841.

(+)-アフィディコリン 生産企業

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38966-21-1, (+)-アフィディコリン キーワード