スルファチアゾール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

  H412：長期的影響により水生生物に有害

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P273：環境への放出を避けること。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

スルファチアゾール 価格

MSDS Information

• 2-(p-Aminobenzenesulfonamido)thiazole

スルファチアゾール 化学特性,用途語,生産方法

• 外観

  白色, 結晶性粉末〜粉末

• 溶解性

  アセトンに溶け、水及びエタノールにほとんど溶けない。

• 解説

  スルファチアゾール,融点200～204 ℃(柱状晶)，175 ℃(六角板状晶)．pKa1 2.1，pKa2 7.43(20 ℃)．効力は強いが全身的な毒性もやや強く，使用法が制限されている．

  森北出版「化学辞典（第2版）
  

• 応用

  肺炎菌，淋(りん)菌，ぶどう状球菌などの感染症に内服またはナトリウム塩を注射する．

• 効能

  抗菌薬, 葉酸合成阻害薬

• 製造

  スルファチアゾール,2-アミノチアゾールとアセチルスルファニルクロリドから合成する．

• 化学的特性

  white to cream powder

• 使用

  Sulfonamide antibacterial.

• 定義

  ChEBI: A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.

• 世界保健機関（WHO）

  Sulfathiazole, a sulfonamide anti-infective agent, was introduced more than 25 years ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Although preparations remain available, use of the drug has been discontinued in many countries.

• 一般的な説明

  White crystalline powder. Is dimorphous: form I is consists of prismatic rods and form II of six-sided plates and prisms. Insoluble in water and soluble in dil aqueous acid and aqueous base.

• 空気と水の反応

  May be sensitive to heat, air and light during long-term storage . Insoluble in water.

• 反応プロフィール

  Sulfathiazole is an amino acid.

• 火災危険

  Flash point data for Sulfathiazole are not available, but Sulfathiazole is probably combustible.

• 応用例（製薬）

  2-Sulfanilamidothiazole. A short-acting compound (half-life c. 4 h) with relatively high activity. Protein binding is c. 75%. Its use has declined because of a high incidence of side effects. It is one of the constituents of triple sulfonamide mixtures, of which local preparations are still available.
  Two compounds, phthalylsulfathiazole (sulfathalidine) and succinylsulfathiazole (sulfasuxidine) owe their activity to the slow liberation of sulfathiazole in the bowel. They are poorly soluble and very little is absorbed after oral administration. They were formerly used in the treatment of intestinal infections and in bowel preparation before surgery. They are available in multi-ingredient preparations in some countries.

• 安全性プロファイル

  Human poison by unspecified route. Experimental poison by intraperitoneal route, Moderately toxic by intravenous, subcutaneous, and parenteral routes. Mildly toxic by ingestion. Human systemic effects by unspecified route: conjunctiva irritation, tubule changes, and allergic skin dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data, Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.

スルファチアゾール 上流と下流の製品情報

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スルファチアゾール スペクトルデータ(¹HNMR、IR1、IR2、MS)

72-14-0, スルファチアゾール キーワード