1-(3-クロロフェニル)-3-[2-(3,3-ジメチルアゼチジン-1-イル)エチル]-2-イミダゾリジノン

1-(3-クロロフェニル)-3-[2-(3,3-ジメチルアゼチジン-1-イル)エチル]-2-イミダゾリジノン 化学特性,用途語,生産方法

• Originator

  MDL 308 ,Dow Chemical

• Manufacturing Process

  A solution of 5.0 g of 1-(m-chlorophenyl)-2-imidazolidinone in 30 ml of dimethylformamide is added at room temperature to a mixture of 1.5 g of 50% NaH (mineral oil emulsion) in 30 ml of dimethylformamide. The reaction mixture is stirred for 1 h at room temperature and then 4.5 g of 3,3-dimethyl- 1-(2-chloroethyl)azetidine are added. The mixture is stirred again at room temperature for 2 h and then it is heated for 5 h at 80°-85°C. The salts are filtered off and the solvent is removed under vacuum. The residue is taken up with 8 ml of 18% HCl and 16 ml of water and extracted with diethyl ether. The water solution is alkalinized by addition of 15% sodium carbonate and then extracted with diethyl ether. By evaporation of the organic layer a residue is obtained that is triturated in light petroleum. Yield of 1-(m- chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-y1)ethyl]-2-imidazolidinone 7.25 g, melting point 84°-85°C (after recrystallization from hexane).

• Therapeutic Function

  Antipsychotic, Neuroleptic

1-(3-クロロフェニル)-3-[2-(3,3-ジメチルアゼチジン-1-イル)エチル]-2-イミダゾリジノン 上流と下流の製品情報

1-(3-クロロフェニル)-3-[2-(3,3-ジメチルアゼチジン-1-イル)エチル]-2-イミダゾリジノン 生産企業

Global(4)Suppliers

51940-78-4, 1-(3-クロロフェニル)-3-[2-(3,3-ジメチルアゼチジン-1-イル)エチル]-2-イミダゾリジノン キーワード