ホスホノぎ酸

ホスホノぎ酸 化学特性,用途語,生産方法

• 定義

  ChEBI: Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to bl ndness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

• 酵素阻害剤

  This pyrophosphate analogue (FWtrisodium salt = 191.95 g/mol; CAS 4428-95- 9), also called foscarnet, exhibits antiherpetic activity. It is a stro+ng inhibitor of viral reverse transcriptases and viral replication as well as Na/phosphate cotransporters. Target (s) : adenylyl cyclase; avian myeloblastosis virus reverse transcriptase; cytomegalovirus DNA polymerase (4-6); DNA- directed DNA polymerase; DNA polymerase b; DNA polymerases, viral; duck hepatitis B virus reverse transcriptase ; Epstein-Barr virus DNA polymerase; equine infectious anemia virus reverse transcriptase; exoribonuclease H; feline immunodeficiency virus reverse transcriptase; geranyl-diphosphate cyclase, or bornyl-diphosphate synthase; guanylyl cyclase; HIV-1 reverse transcriptase; human T-lymphotropic virus type III reverse transcriptase; herpes virus reverse transcriptase ; human hepatitis B virus reverse transcripta+se; Moloney murine leukemia virus reverse transcriptase; Na-dependent phosphate transport (32-38); phosphoenolpyruvate carboxylase; phosphoenolpyruvate mutase; phosphonoacetate hydrolase; phosphonopyruvate hydrolase; ribonuclease H; RNA-directed DNA polymerase; simian immunodeficiency virus reverse transcriptase; and woodchuck hepatitis virus reverse transcriptase.

ホスホノぎ酸 上流と下流の製品情報

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4428-95-9, ホスホノぎ酸 キーワード