マレイン酸ジエチル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H317：アレルギー性皮膚反応を起こすおそれ

  H319：強い眼刺激

  H412：長期的影響により水生生物に有害

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

マレイン酸ジエチル 価格

MSDS Information

• Diethyl maleate

マレイン酸ジエチル 化学特性,用途語,生産方法

• 外観

  無色澄明の液体

• 溶解性

  水に難溶。有機溶媒に可溶。エタノール及びアセトンに溶けやすく、水に極めて溶けにくい。

• 解説

  マレイン酸ジエチル，無色の液体．融点－8.8 ℃，沸点225.3 ℃．d¹⁵₁₅ 1.074．n²⁰_D 1.4416．エタノール，エーテルに可溶，ベンゼン，クロロホルムに難溶，水に不溶．合成樹脂の可塑剤，殺虫剤，殺菌剤，さび止め添加剤として用いられる．

  森北出版「化学辞典（第2版）
  

• 用途

  有機合成原料。

• 製造

  マレイン酸ジエチル，無水マレイン酸を硫酸触媒の存在下，エタノールと加熱すると得られる．

• 化学的特性

  Diethyl maleate is a colorless clear liquid between the temperatures of -10°C (pour point) and 225°C (boiling point). Insoluble in water, soluble in ethanol and ether. its odor type is fruity and its odor at 100% is described as "fruity bananacitrus". It is prohibited by lFRA and theEU because of sensitization and is notused anymore as fragrance.

• 天然物の起源

  Has apparently not been reported to occur in nature.

• 使用

  Diethyl maleate can be used for the preparation of organophosphorus insecticide malathion. It is unsaturated polyester resins that are used in applications, such as reinforced glass fiber for boats, piping, bathtubs, roof panels, etc., and as protective coatings, finishes, and lacquers.

• 定義

  ChEBI: Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10℃) with boiling point 220℃ at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis. It has a role as a glutathione depleting agent. It is a maleate ester and an ethyl ester. It derives from an ethanol.

• 製造方法

  Diethyl maleate is synthesized by the direct esterification of maleic anhydride and ethanol in the presence of sulfuric acid. Esterification is a commonly used reaction in organic synthesis.

• 一般的な説明

  Diethyl maleate is reported to occur in the cabernet sauvignon wine.

• 合成

  5g maleic anhydride, 12g dehydrated alcohol, 0.3g acid zeolite, 15ml benzene are added to the reaction vessel, install water trap, reflux condensing tube, and thermometer on the reaction vessel, reflux water-dividing is carried out in heating, reaction reacts 30min again after occurring without the globule, stops heating, after normal temperature cooling 30min, release water layer, reaction solution washes with water, distill after drying, first steam front-end volatiles, the cut regathering 216 ~ 220 DEG C is product Diethyl maleate.

• 代謝

  α/β-Unsaturated compounds, such as diethyl maleate, react enzymically with gluta thione. The reaction has been demonstrated in fractions of rat liver (Boyland & Chasseaud, 1967) and avian liver (Wit & Snel, 1968). The enzyme differs from other known S-alkyl, S-aryl and S- epoxide transferase enzymes responsible for glutathione-conjugate formation (Boyland & Chasseaud, 1967). Diethyl maleate, administered parenterally to rats, reduced the hepatic glutathione content (Boyland & Chasseaud, 1970; Varga, Fischer & Szily, 1974). The latter workers also showed that diethyl maleate pretreatment of rats inhibited the glutathione conjugation of subsequently-adminis tered bromsulphthalein.

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