2-ヒドロキシ-5-メチルピリジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H318：重篤な眼の損傷

  H335：呼吸器への刺激のおそれ

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

2-ヒドロキシ-5-メチルピリジン 価格

2-ヒドロキシ-5-メチルピリジン 化学特性,用途語,生産方法

• 外観

  白色～黄赤色～緑色粉末～結晶

• 化学的特性

  White Solid

• 使用

  2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides. 2-hydroxy-5-methylpyridine and Iodobenzene were the impurities present in Pirfenidone (PFD) drug substance. PFD is a novel antifibrotic agent approved for mild to moderate Idiopathic pulmonary fibrosis (IPF) as orphan drug[1].

• 合成

  3-cyano-6-hydroxypyridine and sodium lauryl sulfate were added to a mixed solvent of n-butanol and water. Subsequently, the temperature was raised to 50 °C., and sulfuric acid water obtained by dissolving 98% sulfuric acid in water was added dropwise at the temperature. After stirring for about 20 minutes, the mixture was cooled to room temperature, and 5% Pd / C was added. The system was replaced with hydrogen, and hydrogenation was carried out at atmospheric pressure for 6 hours. After the reaction was completed, the catalyst was removed by filtration, and the solution was washed with 10% sodium hydroxide aqueous solution. After partially neutralizing to H = 5 and extraction with n-butanol, a solution of crude 3-methyl-6-hydroxypyridine in butanol was obtained. When this solution was quantified by liquid chromatography, the pass-through rate was 99.2%, and the yield of 2-hydroxy-5-methylpyridine was 83%.

2-ヒドロキシ-5-メチルピリジン 上流と下流の製品情報

2-ヒドロキシ-5-メチルピリジン 生産企業

Global(468)Suppliers

2-ヒドロキシ-5-メチルピリジン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS)

1003-68-5, 2-ヒドロキシ-5-メチルピリジン キーワード