N-(2-ピリジル)-N-(2-チエニルメチル)-N',N'-ジメチルエチレンジアミン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

  P330：口をすすぐこと。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

N-(2-ピリジル)-N-(2-チエニルメチル)-N',N'-ジメチルエチレンジアミン 価格

N-(2-ピリジル)-N-(2-チエニルメチル)-N',N'-ジメチルエチレンジアミン 化学特性,用途語,生産方法

• 化学的特性

  colourless liquid

• 使用

  Methapyrilene is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.

• 定義

  ChEBI: A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.

• 世界保健機関（WHO）

  Methapyrilene, an antihistamine with moderate sedative activity, was introduced in 1947 for the treatment of various allergic conditions and was subsequently incorporated in many over-the-counter sleeping aids. In the early 1970s it was identified as a carcinogen in rats and, although there was no direct evidence that it constitutes a health hazard to man, it was withdrawn in many countries. (Reference: (WHODI) WHO Drug Information, 2, 4, 1979)

• 一般的な説明

  Clear colorless liquid.

• 反応プロフィール

  An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

• 健康ハザード

  ACUTE/CHRONIC HAZARDS: METHAPYRILENE is highly toxic by ingestion.

• 火災危険

  Flash point data for METHAPYRILENE are not available, but METHAPYRILENE is probably combustible.

• 代謝経路

  When methaphenilene is incubated with rat liver microsomes, it is metabolized via N-oxide formation and N-dealkylation which includes removal of the dimethylamino moiety, the thiophenylmethyl moiety of methaphenilene, and the benzyl moiety of pyribenzamine.

N-(2-ピリジル)-N-(2-チエニルメチル)-N',N'-ジメチルエチレンジアミン 上流と下流の製品情報

N-(2-ピリジル)-N-(2-チエニルメチル)-N',N'-ジメチルエチレンジアミン 生産企業

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