フルニソリド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H300：飲み込むと生命に危険

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

フルニソリド 価格

フルニソリド 化学特性,用途語,生産方法

• 化学的特性

  White Solid

• 使用

  Synthetic fluorinated corticosteroid related to Prednisolone (P703740). Antiasthmatic.

• 一般的な説明

  The portion of a flunisolide (AeroBid,Nasarel) dose that is swallowed is rapidly converted to the6β-hydroxy metabolite after first-pass metabolism in theliver. The 6β-hydroxy metabolite is approximately as activeas hydrocortisone itself, but the small amount produced usuallyhas limited systemic effects. Water-soluble conjugatesare inactive.

• 臨床応用

  Flunisolide is an acetone ketal (acetonide) with a 6α-fluoro group and a free C-21 hydroxyl group. The acetonide decreases mineralocorticoid activity, and the 6α-fluoro group increases glucocorticoid activity. It is not a prodrug, because it has the free hydroxyl group at C-21. Flunisolide has approximately 20% of the receptor affinity as budesonide, and approximately 40% of the inhaled dose is systemically bioavailable.

• 代謝

  When administered intranasally or by inhalation, flunisolide is rapidly absorbed from nasal or lung tissue(94). This corticosteroid is efficiently metabolized by the liver to inactive metabolites with no apparent effects on adrenal function with long-term therapy. Flunisolide that is swallowed undergoes extensive first-pass metabolism in the liver, and that which is absorbed directly from the nasopharyngeal mucosa or lung bypasses this initial metabolism. It is not known if the drug undergoes metabolism in the GI tract. Flunisolide is rapidly hydroxylated by CYP3A4 at the 6β position, followed by elimination of the 6α-fluoro group to its more polar 6β-hydroxy metabolite, which attains plasma concentrations that usually are greater than those for flunisolide.

フルニソリド 上流と下流の製品情報

フルニソリド 生産企業

Global(111)Suppliers

3385-03-3, フルニソリド キーワード