2-メチル-8-(フェニルメトキシ)イミダゾ[1,2-a]ピリジン-3-アセトニトリル

2-メチル-8-(フェニルメトキシ)イミダゾ[1,2-a]ピリジン-3-アセトニトリル 価格

2-メチル-8-(フェニルメトキシ)イミダゾ[1,2-a]ピリジン-3-アセトニトリル 化学特性,用途語,生産方法

• 説明

  SCH 28080 is a reversible K⁺-competitive inhibitor of H⁺/K⁺-ATPases that is best known for its ability to block acid secretion through its action against the gastric H⁺/K⁺-ATPase (IC₅₀ = 1.3 μM). It is effective against gastric H⁺/K⁺-ATPases from a variety of species and can inhibit colonic H⁺/K⁺-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H⁺/K⁺-ATPases in non-mammalian organisms and to distinguish the actions of H⁺/K⁺-ATPases from other ATP-dependent transporters.

• 使用

  SCH 28080 is a potent inhibitor of H+,K+-ATPase.

• 生物活性

  Potent inhibitor of H + ,K + -ATPase (IC 50 = 20 nM); binds to the K + recognition site and is competitive with respect to K + . Inhibits gastric acid secretion in vitro and in vivo .

2-メチル-8-(フェニルメトキシ)イミダゾ[1,2-a]ピリジン-3-アセトニトリル 生産企業

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2-メチル-8-(フェニルメトキシ)イミダゾ[1,2-a]ピリジン-3-アセトニトリル スペクトルデータ(¹HNMR)

76081-98-6, 2-メチル-8-(フェニルメトキシ)イミダゾ[1,2-a]ピリジン-3-アセトニトリル キーワード