メラノタンI

化学名:メラノタンI

CAS番号.75921-69-6

英語名:Melanotan-1

CBNumberCB4252333

MFC78H111N21O19

MW1646.85

MOL File75921-69-6.mol

别名

メラノタンI

(NLE4,D-PHE7)-Α-MSH

[Nレ4, D-PHE7]-Α-メラノサイト刺激ホルモン

メラノタンI物理性質

比重(密度)	1.46±0.1 g/cm3(Predicted)
RTECS 番号	OS1830200
貯蔵温度	−20°C
外見	Solid
酸解離定数(Pka)	4.43±0.10(Predicted)
色	White to off-white
水溶解度	Soluble to 0.60 mg/ml in sterile water
シーケンス	Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey	UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS データベース	75921-69-6(CAS DataBase Reference)

安全性情報

WGK Germany

メラノタンI 価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01BCS4003800	1mg	￥32000	(Nle4,D-Phe7)-α-MSH	購入
富士フイルム和光純薬株式会社(wako) W01BCS4003800	5mg	￥126000	(Nle4,D-Phe7)-α-MSH	購入
Sigma-Aldrich Japan M8764	1mg	￥58700	[Nle4, D-Phe7]-α-メラニン細胞刺激ホルモントリフルオロアセタート塩 ≥95% (HPLC)	購入
富士フイルム和光純薬株式会社(wako) W01TOC3013	1mg	￥64000		購入
富士フイルム和光純薬株式会社(wako) W01LKTM7530	5mg	￥40600	[Nレ4, D-Phe7]-α-メラノサイト刺激ホルモン	購入

メラノタンI 化学特性,用途語,生産方法

効能
色素沈着誘発薬
使用
Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.
Origin
Melanotan 1, an alpha MSH analog (Nle4DPhe7-Melanocyte-Stimulating Hormone), is a potent melanocortin developed in the 1980s. Melanotan 2 is a shorter cyclic variant of Melanotan 1 produced in the 1990s. Melanotan 2 was found to increase skin pigmentation at lower cumulative doses than Melanotan 1. However, in clinical trials it was found to have more side effects including nausea somnolence and penile erections[1].
一般的な説明
[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.
Biochem/physiol Actions
[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.
副作用
The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

メラノタンI 生産企業

75921-69-6, メラノタンI キーワード

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