メラノタンII

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

メラノタンII 価格

メラノタンII 化学特性,用途語,生産方法

• 使用

  Melanotan II acetate salt has been used to study its inhibitory effects on feeding and energy expenditure in rats. It is a lab-made chemical that is similar to a hormone found in people. Melanotan II has been shown to have melanogenesis (tanning) and aphrodisiac effects on humans.

• Biochem/physiol Actions

  Melanotan II is a MC3-R/MC4-R melanocortin agonist. It is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.

• 臨床応用

  Melanotan II has been a new treatment for rosacea discussed in the various rosacea support groups on the internet.
  Melanotan I and Melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (a-MSH) that tend to induce skin tanning. Melanotan II has the additional effect of increasing libido.
  Melanotan II is an α-MSH analog which underwent clinical trials for the treatment of erectile dysfunction. Preliminary double-blind, placebo-controlled studies demonstrated the efficacy of melanotan in inducing penile erection in men with erectile dysfunction, although in a very restricted population.Unfortunately, there are no experimental data on the mode of action of melanotan II, as melanotan II is the first α-MSH agonist inducing penile erection when injected peripherally.
  Illustration of the proerectile effect of melanotan II (MT-II) in humans. Placebo (A) or MT-II (B, 25 ug/kg and C, 133 ug/kg) was injected subcutaneously in patients and RigiScan recording was performed from 6 h. Apparent erections developed in 8 of 10 men treated with MT-II. (Reproduced with permission from Wessells H et al. Effect of an alphamelanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 2000; 56:641–646.)

• 副作用

  When given as a shot: Melanotan is POSSIBLY UNSAFE when given as a shot. It can causes nausea, stomachcramps, decreased appetite, flushing, tiredness, yawning, darkened skin, spontaneous erections of the penis, and other side effects. In some people, especially those with light skin, a change in the shape of moles, new moles, and skin cancer, have all occurred in people using melanotan.

• 参考文献

  [1] SOPHIA HATZIIEREMIA. A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice[J]. Rapid Communications in Mass Spectrometry, 2007. DOI:10.1002/rcm.3106.
  [2] WEKWEJTPATRYK   KirykAnna  WojdaUrszula. Melanotan-II reverses memory impairment induced by a short-term HF diet.[J]. Biomedicine & Pharmacotherapy, 2023. DOI:10.1016/j.biopha.2023.115129.
  [3] HJULER K F, LORENTZEN H F. Melanoma Associated with the Use of Melanotan-II[J]. Dermatology, 2013, 228: 34-36. DOI:10.1159/000356389.
  [4] DORR R T, LINES R, LEVINE N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.[J]. Life sciences, 1996, 58 20: 1777-1784. DOI:10.1016/0024-3205(96)00160-9.

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