ヒドラゾベンゼン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H350：発がんのおそれ

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P273：環境への放出を避けること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

ヒドラゾベンゼン 価格

MSDS Information

• N,N'-Diphenylhydrazine

ヒドラゾベンゼン 化学特性,用途語,生産方法

• 外観

  ごくうすい黄色〜うすい黄赤色, 結晶〜結晶性粉末

• 溶解性

  エタノールに溶け、水にほとんど溶けない。

• 解説

  ヒドラゾベンゼン，無色の結晶．融点126～127 ℃．d¹⁶₄ 1.158．エタノールに可溶，ベンゼンに微溶，水に不溶．酸化すればアゾベンゼンを生じ，また酸とともに加熱すれば転位を起こし，発がん性のベンジジンとなる．

  森北出版「化学辞典（第2版）
  

• 用途

  有機合成原料。

• 製法

  ニトロベンゼンをアルカリ水溶液中，亜鉛末で還元すると得られるヒドラゾベンゼン．

• 説明

  Diphenylhydrazine is a man-made chemical that occurs in two isomeric forms: 1,1-diphenylhydrazine and 1,2-diphenylhdrazine. Diphenylhydrazine is produced by the reduction of nitrobenzene. Little or no information is available for 1,1-diphenylhydrazine. Most toxicological and use data pertain to 1,2-diphenylhydrazine.

• 化学的特性

  yellow crystalline powder

• 使用

  Previously, 1,2-diphenylhydrazine was used for producing benzidine that was used in the synthesis of benzidine-based dyes. However, these dyes are no longer produced in the United States. The primary use of 1,2-diphenylhydrazine is in the production of the anti-inflammatory agent phenylbutazone and sulfinpyrazone, a uricosuric agent.

• 一般的な説明

  Orange powder or a bright orange crystalline solid.

• 空気と水の反応

  1,2-Diphenylhydrazine oxidizes in air. 1,2-Diphenylhydrazine decomposes in acid solutions. Insoluble in water.

• 反応プロフィール

  1,2-Diphenylhydrazine is a mild reducing agent. Incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. Interaction with perchloryl fluoride in the presence of a dilutent below 32°F has caused separation of explosive solids. Is readily oxidized by nitric acid, silver nitrate or permanganate. Is reduced under alkaline conditions .

• 健康ハザード

  1,2-Diphenylhydrazine is a liver toxin in rodents and appears to be carcinogenic in experimental animals.

• 火災危険

  Flash point data for 1,2-Diphenylhydrazine are not available; however, 1,2-Diphenylhydrazine is probably combustible.

• 発がん性

  Hydrazobenzene is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• 環境運命予測

  Biological. When 5 and 10 mg/L of diphenylhydrazine was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, 80 and 72% biodegradation, respectively, were observed after 7 d (Tabak et al., 1981).
  Chemical/Physical. Wet oxidation of 1,2-diphenylhydrazine at 320 °C yielded formic and acetic acids (Randall and Knopp, 1980). 1,2-Diphenylhydrazine will not hydrolyze (Kollig, 1993).
  At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 16,000, 160, 1.5, and 0.015 mg/g, respectively (Dobbs and Cohen, 1980).

• 純化方法

  Crystallise hydrazobenzene from hot EtOH containing a little ammonium sulfide or H2SO3 (to prevent atmospheric oxidation), preferably under N2. Dry it in a vacuum desiccator, and store it in the dark or under N2. Alternatively, crystallise it from pet ether (b 60-100o) to constant absorption spectrum. It is almost colourless but in air it turns yellow, then red with the formation of azobenzene. The hydrochloride crystallises from EtOH and has m 163-164o(dec); however, hydrazobenzene readily rearranges to benzidine in the presence of acid. The picrate crystallises from *C6H6 and has m 123o(dec). [Beilstein 15 H 123.]

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ヒドラゾベンゼン スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS、Raman)

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