3-ヒドロキシ-1-メチルピリジニウム化学構造式

3-ヒドロキシ-1-メチルピリジニウム

化学名:3-ヒドロキシ-1-メチルピリジニウム

CAS番号.15876-67-2

英語名:distigmine bromide

CBNumberCB3942240

MFC22H32N4O4.2Br

MW0

MOL File15876-67-2.mol

别名

3,3'-[1,6-ヘキサンジイルビス[[(メチルイミノ)カルボニル]オキシ]]ビス(1-メチルピリジニウム)·ジブロミド

ジスチグミン

デニスパン

3-ヒドロキシ-1-メチルピリジニウム物理性質

貯蔵温度	Sealed in dry,Room Temperature
溶解性	DMSO:100.0(Max Conc. mg/mL);178.47(Max Conc. mM)
外見	Solid
色	White to Off-White
安定性：	Hygroscopic, Temperature Sensitive

危険有害性情報のコード(GHS)

3-ヒドロキシ-1-メチルピリジニウム化学特性,用途語,生産方法

効能
アセチルコリンエステラーゼ阻害薬
商品名
ウブレチド (鳥居薬品); ウブレチド (鳥居薬品); ウブレチド (鳥居薬品); ジスチグミン臭化物 (武田テバ薬品)
Originator
Ubretid,Hormonchemie,W. Germany,1966
Manufacturing Process
2 parts of sodium are dissolved in 24 parts of methanol and to the solution of sodium methylate formed 8.25 parts of 3-oxypyridine and 90 parts of xylene (mixture of isomers) are added. Then the mixture is distilled in an atmosphere of nitrogen as protecting gas until the boiling point of xylene is reached and the methanol is completely removed. The remainder is brought together with a solution of 11.7 parts of hexamethylene-bis-(N-methyl carbamic acid chloride) in 45 parts of xylene and maintained 4 hours at a temperature of80°C under vigorous stirring.
After having been cooled it is washed three times in water, three times in a 5% solution of caustic soda, and then another three times in water. The solution in xylene is dried over sodium sulfate and the xylene is completely distilled off in vacuo. Thus 11.0 parts of hexamethylene-bis-(Nmethylcarbamic acid-3-pyridyl ester) are obtained.
7.3 parts of hexamethylene-bis-(N-methyl carbamic acid-3-pyridyl ester) are dissolved in 120 parts of acetone, then 22 parts of methyl bromide are added and the mixture is left to stand at room temperature until the reaction is finished, whereby crystals are precipitated. The reaction product after being drawn off and dried (9.9 parts) can be purified by dissolving in acetic acid and precipitating with methyl ethyl ketone. The hexamethylene-bis-(N-methyl carbamic acid-3-pyridyl ester bromomethylate) has a micro melting point between 147°C and 150°C.
Therapeutic Function
Cholinesterase inhibitor

3-ヒドロキシ-1-メチルピリジニウム上流と下流の製品情報

3-ヒドロキシ-1-メチルピリジニウム生産企業

15876-67-2, 3-ヒドロキシ-1-メチルピリジニウムキーワード

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3-ヒドロキシ-1-メチルピリジニウム

危険有害性情報のコード(GHS)

3-ヒドロキシ-1-メチルピリジニウム 化学特性,用途語,生産方法

3-ヒドロキシ-1-メチルピリジニウム 上流と下流の製品情報

3-ヒドロキシ-1-メチルピリジニウム 生産企業

15876-67-2, 3-ヒドロキシ-1-メチルピリジニウム キーワード

3-ヒドロキシ-1-メチルピリジニウム化学特性,用途語,生産方法

3-ヒドロキシ-1-メチルピリジニウム上流と下流の製品情報

3-ヒドロキシ-1-メチルピリジニウム生産企業

15876-67-2, 3-ヒドロキシ-1-メチルピリジニウムキーワード