10-[(1-メチル-3-ピペリジニル)メチル]-10H-フェノチアジン・塩酸塩

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P501：内容物/容器を．．．に廃棄すること。

10-[(1-メチル-3-ピペリジニル)メチル]-10H-フェノチアジン・塩酸塩 化学特性,用途語,生産方法

• Originator

  Pacatal,Warner Lambert,US,1957

• Manufacturing Process

  A 500 cc flask equipped with a mechanical stirrer, reflux condenser and a soda-lime tube was filled with 230 cc of absolute xylene, 27.5 g of 1-methyl3-bromomethylpiperidine, 53.3 g of phenothiazine and 14.2 g of finely powdered sodium amide, and the solution was heated under reflux for 6 hours. After cooling water was added and the batch was extracted with ether. As the hydrochloric acid salt of the obtained phenothiazine derivative is difficultly soluble in water, the further processing was carried out by way of the acetate. The etheric solution was extracted several times in a separating funnel with dilute acetic acid. The combined aqueous extracts were basified, extracted with ether, dried with potassium carbonate and, after removal of the ether, distilled in vacuo.
  Yield = 64%; boiling point 230°C to 235°C at 4 mm; melting point of hydrochloride is 180°C to 181°C.

• Therapeutic Function

  Tranquilizer

10-[(1-メチル-3-ピペリジニル)メチル]-10H-フェノチアジン・塩酸塩 上流と下流の製品情報

10-[(1-メチル-3-ピペリジニル)メチル]-10H-フェノチアジン・塩酸塩 生産企業

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