ブフェトロール塩酸塩

ブフェトロール塩酸塩 化学特性,用途語,生産方法

• 効能

  抗不整脈薬, 血管拡張薬, β遮断薬

• 商品名

  アドビオール (田辺三菱製薬)

• Originator

  Bufetolol,ZYF Pharm

• Manufacturing Process

  To a solution of 1 gramm equivalent (g-eq.) of 1-bromo-3-[2- (tetrahydrofuran-2-yloxy)phenoxy]propan-2-ol in 30 ml of ethanol is added 1 g-eq. of t-butylamine, the mixture is refluxed for 6 hours, and then the ethanol is distilled off. The residue is dissolved in benzene and the solution is extracted twice with 5% oxalic acid. The aqueous extract is made alkaline with potassium hydroxide and the isolated oil is extracted with benzene. The benzene extract is dried over potassium carbonate and the benzene is distilled off to give of oily 1-(t-butylamino)-3-(o-((tetrahydrofurfuryl)oxy)phenoxy)-2- propanol. The corresponding acid fumarate melts at 128°-132°C.

• Therapeutic Function

  Antiarrhythmic, Beta-adrenergic blocker

ブフェトロール塩酸塩 上流と下流の製品情報

35108-88-4, ブフェトロール塩酸塩 キーワード