1,3-ビス(2,6-ジイソプロピルフェニル)イミダゾリウムクロリド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

1,3-ビス(2,6-ジイソプロピルフェニル)イミダゾリウムクロリド 価格

1,3-ビス(2,6-ジイソプロピルフェニル)イミダゾリウムクロリド 化学特性,用途語,生産方法

• 外観

  白色～うすい黄色、結晶性粉末～粉末

• 化学的特性

  White to Light yellow to Light orange powder to crystal. soluble in methanol.

• 使用

  1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is also used in organic synthesis, as well as a pharmaceutical intermediate. 1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is used as a reagent in the synthesis of NHC Copper(I) complexes bearing dipyridylamine ligands which exhibit interesting luminescent properties and are potential candidates for organic light-emitting diode applications. 1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is also used as a reagent in the synthesis of 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic Acid Methyl Ester (D476595); the methyl ester derivative of the drug Vadimezan (V084950).

• 主な応用

  1,3-Bis(2,6-Diisopropylphenyl)imidazolium chloride is also used as a reagent in the synthesis of 5,6-Dimethyl-9-Oxo-9H-xanthene-4-acetic acid methyl ester; the methyl ester derivative of the drug Vadimezan. Moreover, it is an imidazolium salt that is active against all stages of Trypanosoma Cruzi and may represent a promising candidate for treatment of Chagas disease.

• 反応性

  Precursor to Pd catalysts used in C-N and C-C coupling reactions.
  Ligand used in double carbonylation reactions.
  Precursor to Ni catalysts used in C-N coupling reactions.
  Precursor to Cu catalysts used in copper hydride reactions.
  Ligand used in Ru-catalyzed carbonylative C-H cyclization of 2-aryl phenols.
  

• 安全性

  H300 (37.84%): Fatal if swallowed [Danger Acute toxicity, oral]
  H315 (62.16%): Causes skin irritation [Warning Skin corrosion/irritation]
  H317 (37.84%): May cause an allergic skin reaction [Warning Sensitization, Skin]
  H318 (37.84%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  H319 (62.16%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
  H400 (37.84%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
  H410 (37.84%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

• 参考文献

  Suzuki-Miyaura Reaction
  Esterification of α-Halo-α,β-unsaturated Aldehydes by Using a Carbene Catalyst
  Cycloaddition of CO2 to Epoxides Catalyzed by N-Heterocyclic Carbene (NHC)–ZnBr2 System under Mild Conditions
  
  [1] Yan C, et al. An efficient and recyclable iron(III)-containing imidazolium salt catalyst for cross-coupling of aryl Grignard reagents with alkyl halides. Science Bulletin, 2012; 57: 1953–1958.
  [2] Hans M, et al. Efficient synthetic protocols for the preparation of common N-heterocyclic carbene precursors. Beilstein Journal of Organic Chemistry, 2015; 11: 2318–2325.

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