ｔ－ブチルヒドロキシアニソール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

  H351：発がんのおそれの疑い

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P281：指定された個人用保護具を使用すること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

  P405：施錠して保管すること。

ｔ－ブチルヒドロキシアニソール 価格

MSDS Information

• 3(2)-tert-Butyl-4-hydroxyanisole

ｔ－ブチルヒドロキシアニソール 化学特性,用途語,生産方法

• 外観

  白色〜わずかにうすい黄褐色, 結晶〜結晶性粉末

• 定義

  BHAは、ブチルヒドロキシアニソールの表示名称である。本品は4-メトキシフェノールにt-ブチル基が置換したものの混合物である。主に3-t-ブチル-4-ヒドロキシアニソールからなり、少量の2-t-ブチル-4-ヒドロキシアニソールを含み、次の化学式で表される。

• 溶解性

  エタノール（95 ）及びアセトンに極めて溶けやすく、水にほとんど溶けない。

• 用途

  プラスチック添加用酸化防止剤,食品添加物

• 化粧品の成分用途

  酸化防止剤、香料

• 説明

  Butylated hydroxyanisole (BHA) is an antioxidant widely used in food. Because it is contained in pastry, it can induce sensitization in caterers.

• 化学的特性

  Butylated hydroxyanisole occurs as a white or almost white crystalline powder or a yellowish-white waxy solid with a faint, characteristic aromatic odor.

• 天然物の起源

  BHA is not known to occur as a natural product.

• 使用

  Butylated Hydroxyanisole is an antioxidant consisting of a mixture of two isomers of tert-butyl-4-hydroxyanisole. Butylated Hydroxyanisole is used in food preservation as it antioxidant properties pre vent food from becoming rancid. Butylated Hydroxyanisoleas is also used in animal feed, petroleum products, and cosmetics.

• 調製方法

  Prepared by the reaction of p-methoxyphenol with isobutene.

• 定義

  A mixture of 2- and 3-tert-4-methoxyphenol.

• 一般的な説明

  White, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Butylated hydroxyanisole degrades with prolonged exposure to sunlight. Exhibits antioxidant properties and synergism with acids, BHT, propyl gallate, hydroquinone, methionine, lecithin and thiodipropionic acid. Butylated hydroxyanisole exhibits antioxidant properties as a scavenger of free radicals. Butylated hydroxyanisole is incompatible with oxidizing agents and ferric salts.

• 危険性

  Toxic by ingestion. Use in foods restricted; consult FDA regulations.

• 火災危険

  Butylated hydroxyanisole is combustible.

• 応用例（製薬）

  Butylated hydroxyanisole is an antioxidant with some antimicrobial properties. It is used in a wide range of cosmetics, foods, and pharmaceuticals. When used in foods, it is used to delay or prevent oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
  Butylated hydroxyanisole is frequently used in combination with other antioxidants, particularly butylated hydroxytoluene and alkyl gallates, and with sequestrants or synergists such as citric acid.
  FDA regulations direct that the total content of antioxidant in vegetable oils and direct food additives shall not exceed 0.02% w/w (200 ppm) of fat or oil content or essential (volatile) oil content of food.
  USDA regulations require that the total content of antioxidant shall not exceed 0.01% w/w (100 ppm) of any one antioxidant or 0.02% w/w combined total of any antioxidant combination in animal fats.
  Japanese regulations allow up to 1 g/kg in animal fats.

• 接触アレルゲン

  BHA is an antioxidant widely used in cosmetics and food. Contained in pastry, it can induce sensitization in caterers.

• 安全性プロファイル

  Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid and irritating fumes

• 安全性

  Butylated hydroxyanisole is absorbed from the gastrointestinal tract and is metabolized and excreted in the urine with less than 1% unchanged within 24 hours of ingestion. Although there have been some isolated reports of adverse skin reactions to butylated hydroxyanisole, it is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
  Concern over the use of butylated hydroxyanisole has occurred following long-term animal feeding studies. Although previous studies in rats and mice fed butylated hydroxyanisole at several hundred times the US-permitted level in the human diet showed no adverse effects, a study in which rats, hamsters, and mice were fed butylated hydroxyanisole at 1–2% of the diet produced benign and malignant tumors of the forestomach, but in no other sites. However, humans do not have any region of the stomach comparable to the rodent forestomach and studies in animals that also do not have a comparable organ (dogs, monkeys, and guinea pigs) showed no adverse effects. Thus, the weight of evidence does not support any relevance to the human diet where butylated hydroxyanisole is ingested at much lower levels. The WHO acceptable daily intake of butylated hydroxyanisole has been set at 500 μg/kg body-weight.
  LD₅₀ (mouse, oral): 1.1–2.0 g/kg
  LD₅₀ (rabbit, oral): 2.1 g/kg
  LD₅₀ (rat, IP): 0.88 g/kg
  LD₅₀ (rat, oral): 2.0 g/kg

• 発がん性

  Butylated hydroxyanisole (BHA) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• 環境運命予測

  The metabolites of BHA can bind to cellular macromolecules, such as proteins and DNA, and cause toxicity.

• 貯蔵

  Exposure to light causes discoloration and loss of activity. Butylated hydroxyanisole should be stored in a well-closed container, protected from light, in a cool, dry place.

• 輸送方法

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9— Miscellaneous hazardous material, Technical Name Required

• 不和合性

  Butylated hydroxyanisole is phenolic and undergoes reactions characteristic of phenols. It is incompatible with oxidizing agents and ferric salts. Trace quantities of metals and exposure to light cause discoloration and loss of activity.

• 廃棄物の処理

  Suggested: Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed.

• 規制状況(Regulatory Status)

  GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, and sublingual, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

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