ｔ－ブチルヒドロキシアニソール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H411：長期的影響により水生生物に毒性

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P273：環境への放出を避けること。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P391：漏出物を回収すること。

  P501：内容物/容器を．．．に廃棄すること。

ｔ－ブチルヒドロキシアニソール 価格

MSDS Information

• 3(2)-tert-Butyl-4-hydroxyanisole

ｔ－ブチルヒドロキシアニソール 化学特性,用途語,生産方法

• 外観

  白色〜わずかにうすい黄褐色, 結晶〜結晶性粉末

• 定義

  BHAは、ブチルヒドロキシアニソールの表示名称である。本品は4-メトキシフェノールにt-ブチル基が置換したものの混合物である。主に3-t-ブチル-4-ヒドロキシアニソールからなり、少量の2-t-ブチル-4-ヒドロキシアニソールを含み、次の化学式で表される。

• 溶解性

  エタノール（95 ）及びアセトンに極めて溶けやすく、水にほとんど溶けない。

• 無機性値/有機性値

  135/200

• 用途

  プラスチック添加用酸化防止剤,食品添加物

• 化粧品の成分用途

  酸化防止剤、香料

• 展望

  BHAの使用に関する懸念が高まる中多くの研究者や製造業者は自然由来の抗酸化剤に焦点を当てていますビタミンEトコフェロールやローズマリー抽出物など自然界に存在する抗酸化物質はBHAの安全な代替品として注目されていますこれらの自然由来成分は消費者からの健康志向や天然成分への好みに応えるものであり製品の品質保持能力もBHAに匹敵することが示されています

• 化学的特性

  ブチルヒドロキシアニソールBHAは化学式C11H16O2を持つ合成抗酸化剤です食品化粧品医薬品の保存料として広く使用されていますこの物質は主に脂質の酸化を防ぐことにより製品の品質を保つために利用されますBHAは2テルトブチル4ヒドロキシアニソールとも呼ばれ脂溶性が高いため油脂成分を多く含む食品に特に有効です

• 説明

  Butylated hydroxyanisole (BHA) is an antioxidant widely used in food. Because it is contained in pastry, it can induce sensitization in caterers.

• 化学的特性

  Butylated hydroxyanisole occurs as a white or almost white crystalline powder or a yellowish-white waxy solid with a faint, characteristic aromatic odor.

• 天然物の起源

  BHA is not known to occur as a natural product.

• 使用

  Butylated Hydroxyanisole is an antioxidant consisting of a mixture of two isomers of tert-butyl-4-hydroxyanisole. Butylated Hydroxyanisole is used in food preservation as it antioxidant properties pre vent food from becoming rancid. Butylated Hydroxyanisoleas is also used in animal feed, petroleum products, and cosmetics.

• 定義

  A mixture of 2- and 3-tert-4-methoxyphenol.

• 調製方法

  Prepared by the reaction of p-methoxyphenol with isobutene.

• 安全性

  BHAの安全性については世界保健機関WHOの国際がん研究機関IARCによってヒトに対する発がん性が「おそらくない」と分類されていますしかし一部の研究では高濃度でのBHAの摂取が動物実験で潜在的な健康リスクを示すことが報告されていますそのため多くの国ではBHAの使用量に上限が設けられており食品や化粧品に安全な範囲内でのみ使用が許可されています

• 一般的な説明

  White, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Butylated hydroxyanisole degrades with prolonged exposure to sunlight. Exhibits antioxidant properties and synergism with acids, BHT, propyl gallate, hydroquinone, methionine, lecithin and thiodipropionic acid. Butylated hydroxyanisole exhibits antioxidant properties as a scavenger of free radicals. Butylated hydroxyanisole is incompatible with oxidizing agents and ferric salts.

• 危険性

  Toxic by ingestion. Use in foods restricted; consult FDA regulations.

• 火災危険

  Butylated hydroxyanisole is combustible.

• 化学性质

  置換基を有する芳香族化合物

• 応用例（製薬）

  Butylated hydroxyanisole is an antioxidant with some antimicrobial properties. It is used in a wide range of cosmetics, foods, and pharmaceuticals. When used in foods, it is used to delay or prevent oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
  Butylated hydroxyanisole is frequently used in combination with other antioxidants, particularly butylated hydroxytoluene and alkyl gallates, and with sequestrants or synergists such as citric acid.
  FDA regulations direct that the total content of antioxidant in vegetable oils and direct food additives shall not exceed 0.02% w/w (200 ppm) of fat or oil content or essential (volatile) oil content of food.
  USDA regulations require that the total content of antioxidant shall not exceed 0.01% w/w (100 ppm) of any one antioxidant or 0.02% w/w combined total of any antioxidant combination in animal fats.
  Japanese regulations allow up to 1 g/kg in animal fats.

• 接触アレルゲン

  BHA is an antioxidant widely used in cosmetics and food. Contained in pastry, it can induce sensitization in caterers.

• 安全性プロファイル

  Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid and irritating fumes

• 安全性

  Butylated hydroxyanisole is absorbed from the gastrointestinal tract and is metabolized and excreted in the urine with less than 1% unchanged within 24 hours of ingestion. Although there have been some isolated reports of adverse skin reactions to butylated hydroxyanisole, it is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
  Concern over the use of butylated hydroxyanisole has occurred following long-term animal feeding studies. Although previous studies in rats and mice fed butylated hydroxyanisole at several hundred times the US-permitted level in the human diet showed no adverse effects, a study in which rats, hamsters, and mice were fed butylated hydroxyanisole at 1–2% of the diet produced benign and malignant tumors of the forestomach, but in no other sites. However, humans do not have any region of the stomach comparable to the rodent forestomach and studies in animals that also do not have a comparable organ (dogs, monkeys, and guinea pigs) showed no adverse effects. Thus, the weight of evidence does not support any relevance to the human diet where butylated hydroxyanisole is ingested at much lower levels. The WHO acceptable daily intake of butylated hydroxyanisole has been set at 500 μg/kg body-weight.
  LD₅₀ (mouse, oral): 1.1–2.0 g/kg
  LD₅₀ (rabbit, oral): 2.1 g/kg
  LD₅₀ (rat, IP): 0.88 g/kg
  LD₅₀ (rat, oral): 2.0 g/kg

• 発がん性

  Butylated hydroxyanisole (BHA) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• 環境運命予測

  The metabolites of BHA can bind to cellular macromolecules, such as proteins and DNA, and cause toxicity.

• 貯蔵

  Exposure to light causes discoloration and loss of activity. Butylated hydroxyanisole should be stored in a well-closed container, protected from light, in a cool, dry place.

• 輸送方法

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9— Miscellaneous hazardous material, Technical Name Required

• 不和合性

  Butylated hydroxyanisole is phenolic and undergoes reactions characteristic of phenols. It is incompatible with oxidizing agents and ferric salts. Trace quantities of metals and exposure to light cause discoloration and loss of activity.

• 廃棄物の処理

  Suggested: Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed.

• 規制状況(Regulatory Status)

  GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, and sublingual, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

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