1,4-ブタンスルトン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H317：アレルギー性皮膚反応を起こすおそれ

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

  H351：発がんのおそれの疑い

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

1,4-ブタンスルトン 価格

MSDS Information

• 1,4-Butane sultone

1,4-ブタンスルトン 化学特性,用途語,生産方法

• 外観

  無色～わずかにうすい黄色, 澄明の液体

• 溶解性

  水に難溶, エタノール, アセトンに易溶。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。

• 用途

  有機合成原料。

• 説明

  1,4-Butane sultone is an impurity in sulfobutyl ether β-cyclodextrin (SBE-β-CD), and has been reported to be a weak carcinogen. 1,4-Butane sultone can be used for preparation of Brnsted acidic ionic liquids and the ionic liquid is green, highly water soluble, thermally stable, specific and catalytically stable, and can be used for the preparation of symmetrical 3,3'-diaryloxyoctanone compounds^[1-2].

• 化学的特性

  Butanesultone is a viscous, clear, colourless – or yellowish/brown – and odourless liquid. When heated, vapours of butanesultone are known to form explosive mixtures with air and are reported to cause explosion hazards.

• 使用

  1,4-Butane Sultone is an alkylating agent with weak carcinogenic activity.

• 主な応用

  1,4-Butane sultone is an intermediate widely used for sulfonated surfactants.It is also applied in photo development and electroplating.It is used as the Intermediate for the production of APIs.It used in sulfobutylether-β-cyclodextrin（SEBCD).

• 化学反応性

  The reactivity of 1,4-butane sultone:
  Under conditions involving an excess of diol, the reaction of 1,4-butanesultone (BS) with 1,4-butanediol (BD) yields only a negligible amount of (4-hydroxybutoxy)butane-1-sulfonic acid (BDSA), and the formation of tetrahydrofuran (THF) (accounting for 30 mol% of the initial BD) is observed. BD was reacted with Na₂CO₃, used as the base, at a molar ratio of 10:1 for 1 hour at room temperature. After distilling off the unreacted BD, BS was added. The resulting BDSS was purified by precipitation, yielding a 45% yield^[3].
  

• 安全性プロファイル

  Suspected carcinogen with experimental tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. See also SULFONATES. When heated to decomposition it emits toxic fumes of SOx

• 合成

  Performing sulfonation on 3-butylene-1-alcohol or 3-butylene-1-chlorine serving as a raw material and a sulfonating agent under the oxidation-reduction of an initiator;performing acidification after the reaction is finished;performing lactonization by high vacuum dehydration cyclization and azeotropic dehydration cyclization;and finally refining to obtain a 1,4-butane sultone finished product.

1,4-ブタンスルトン 上流と下流の製品情報

1,4-ブタンスルトン 生産企業

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1,4-ブタンスルトン スペクトルデータ(¹HNMR、¹³CNMR、IR1、Raman)

1633-83-6, 1,4-ブタンスルトン キーワード