3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P330：口をすすぐこと。

  P501：内容物/容器を．．．に廃棄すること。

3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE 価格

3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE 化学特性,用途語,生産方法

• Originator

  Clobenztropine,Onbio Inc.

• Manufacturing Process

  A solution of 28.2 g (0.2 mol) of 3-tropanol is prepared in 50 ml of xylol, and to this solution is added 23.8 g (0.1 mol) of 4-chlorobenzhydryl chloride. The resultant solution is heated for 7 h at 145°-155°C, following which the mixture is cooled and filtered. The clear filtrate thus obtained is washed with 50 ml of 5% aqueous potassium carbonate solution and then with three successive 25 ml portion of water. The xylol solution is then extracted with three successive 50 ml portions of 2 N hydrochloric acid. The xylol layer is discarded and the acid extracts are combined and rendered strongly basic by the addition of 22.5% aqueous potassium hydroxide, resulting in the formation of an oily base which separates and which is then extracted with
  benzol, from which the benzol is evaporated to yield crude 3-(4'- chlorobenzhydryloxy)tropane as a brown oil.
  2.0 g of 3-(4'-chlorobenzhydryloxy)tropane is treated with 10 ml of 4.5 N isopropanoic acid hydrogen chloride solution, and the pasty mixture which results is diluted with approximately 30 ml of absolute ether. A solid product is formed which is separated by filtration and then washed with absolute ether. The product is then purified by dissolving it in hot isopropanol, followed by clarification with activated charcoal. Upon cooling the filtrate, the 3-(4'- chlorophenylbenzyloxy)tropane separates as a crystalline powder, melting point 215°-217°C.
  In practice it is usually used as hydrochloride.

• Therapeutic Function

  Antihistaminic

3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE 上流と下流の製品情報

3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE 生産企業

Global(15)Suppliers

3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE スペクトルデータ(¹HNMR)