エンフルラン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

エンフルラン 価格

エンフルラン 化学特性,用途語,生産方法

• 解説

  エンフルレン，麻酔導入，覚醒が遅く，代謝産物が腎臓障害を起こす欠点がある。(4)エンフルレンenflurane　1960年代にアメリカで開発された。麻酔作用は強力で，導入，覚醒は速い。

  株式会社平凡社 世界大百科事典 第２版について | 情報
  

• 用途

  吸入麻酔薬

• 効能

  吸入麻酔薬

• 化学的特性

  Enflurane is a clear, colorless liquid that easily turns into a nonflammable gas. Mild, sweet odor

• 使用

  Clinical anesthetic.

• 定義

  ChEBI: An ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups.

• 一般的な説明

  Enflurane is a volatile liquid (bp＝56.5°C) with a blood:gas partition coefficient of 1.8 and an MAC of 1.68%.Approximately 2% to 8% of the drug is metabolized primarilyat the chlorofluoromethyl carbon. Little chlorofluoroaceticacid is produced suggesting minor metabolism at thedifluoromethyl carbon. Difluoromethoxydifluoroacetate andfluoride ion have been reported as metabolites. Enfluranemay increase heart rate, cause cardiac arrhythmias, increasecerebral blood flow, and increase intracranial pressure but allto a smaller degree than halothane. Enflurane also causeselectroencephalographic (EEG) patterns consistent withelectrical seizure activity. It has caused tonic–clonic convulsiveactivity in patients when used at high concentrations orduring profound hypocarbic periods. Enflurane is thereforenot recommended in patients with seizure disorders.

• 反応プロフィール

  The material 2-CHLORO-1,1,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER is incompatible with the following oxidizing materials, peroxides, combustible materials. Although nonflammable, a fire may cause 2-CHLORO-1,1,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER to decompose to toxic compounds including phosgene, hydrogen chloride, and hydrogen fluoride. Decomposes slowly in the light.

• 危険性

  Volatile with anesthetic properties, but nonflammable. Cardiac and central nervous system impairment. Questionable carcinogen.

• 火災危険

  Noncombustible liquid; flash point >94°C (200°F); low reactivity. Pressure buildup in a closed bottle may occur at elevated temper atures.

• 臨床応用

  Enflurane was introduced into medical practice in the United States in 1973 and is a clear, colorless, nonflammable general liquid with a mild, sweet odor. Although relatively stable chemically, enflurane does not attack aluminum, copper, iron, or brass and is soluble in rubber (partition coefficient = 74), which can prolong induction/recovery times, as seen with halothane.Enflurane has an intermediate solubility in blood and significant potency. Most of its pharmacological properties are similar to those of halothane, although there may be slightly less nausea, vomiting, arrhythmias, and postoperative shivering than observed with halothane. High concentrations of enflurane, however, are more likely to produce convulsions and circulatory depression. Enflurane also relaxes the uterus and, thus, should not be used as an anesthetic during labor. Metabolism via CYP2E1 accounts for 2% of an inhaled dose and includes transformation to the fluoride ion and fluoromethoxydifluoroacetic acid. During recovery, enflurane leaves the fatty tissues rapidly and, therefore, is not available for a prolonged period of time for significant metabolism to proceed.

• 安全性プロファイル

  Mildly toxic by inhalation, ingestion, and subcutaneous routes. Human systemic effects by inhalation: decreased urine volume or anuria. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. An eye irritant. Questionable carcinogen with experimental carcinogenic data. An anesthetic. When heated to decomposition it emits very toxic fumes of Fand Cl-. See also ETHERS.

• 職業ばく露

  FDA-proprietary drug, used as an anesthetic (gas). Axphyxiant

• 輸送方法

  UN1851 Medicine, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. Cylinders must be transported in a secure upright position, in a wellventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner.

• 不和合性

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. Decomposes on heating, forming toxic and corrosive fumes of hydrogen chloride, hydrogen fluoride, and phosgene. Decomposes in strong sunlight

• 廃棄物の処理

  Return refillable compressed gas cylinders to supplier

エンフルラン 上流と下流の製品情報

エンフルラン 生産企業

Global(116)Suppliers

エンフルラン スペクトルデータ(¹HNMR、FT-IR)

13838-16-9, エンフルラン キーワード