テノホビルジソプロキシル

化学名:テノホビルジソプロキシル

CAS番号.201341-05-1

英語名:Tenofovir disoproxil

CBNumberCB0949152

MFC19H30N5O10P

MW519.44

MOL File201341-05-1.mol

别名

[[(R)-1-メチル-2-(6-アミノ-9H-プリン-9-イル)エトキシ]メチル]ホスホン酸ビス[[(イソプロポキシカルボニル)オキシ]メチル]

9-[(R)-2-[[ビス[(イソプロピルオキシカルボニルオキシ)メトキシ]ホスフィニル]メトキシ]プロピル]-9H-プリン-6-アミン

[[(1R)-1-メチル-2-(6-アミノ-9H-プリン-9-イル)エトキシ]メチル]ホスホン酸ビス[(イソプロポキシカルボニルオキシ)メチル]

テノホビルジソプロキシル物理性質

沸点	642.7±65.0 °C(Predicted)
比重(密度)	1.45±0.1 g/cm3(Predicted)
貯蔵温度	Keep in dark place,Inert atmosphere,2-8°C
溶解性	DMSO: ≥ 38 mg/mL (73.16 mM)
酸解離定数(Pka)	4.20±0.10(Predicted)
外見	Solid
色	White to off-white
CAS データベース	201341-05-1

テノホビルジソプロキシル化学特性,用途語,生産方法

説明
Tenofovir disoproxil is a prodrug in a manner similar to that of adefovir dipivoxil. In both cases, the phosphate esters are removed through the action of plasma esterase, leading in this case to tenofovir, which differs from adefovir by the presence of the indicated methyl group. Tenofovir disoproxil exhibits good bioavailability (25%), which is improved in the presence of food (35%). The drug is approved for the treatment of HIV infections in adult patients. Tenofovir diphosphate is an HIV RT inhibitor. The active form of tenofovir is the tenofovir diphosphate, which competes with dATP for incorporation into viral DNA, and when incorporated, tenofovir diphosphate results in premature termination of DNA growth and inhibition of DNA polymerase. Tenofovir disoproxil is indicated for treatment-experienced patients with HIV-1. The drug also appears to be effective in treatment-naive patients, but initial approval is for treatment-experienced patients. The drug is administered as one tablet taken once daily. It is recommended that the drug be combined with other RT inhibitors or HIV PIs, which results in additive or synergistic activity.
使用
Tenofovir Disoproxil is a therapeutic option for nucleos(t)ide analog (NA)-experienced chronic hepatitis B (CHB) patients infected with hepatitis B virus (HBV). Also, it is an intermediate used in the synthesis of Tenofovir Disoproxil Dimer (T018515), which is a Tenofovir Disoproxil impurity.
定義
ChEBI: An organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.
一般的な説明
Tenofovir disoproxil is a prodrug analogously with abacavir.Plasma and tissue esterases cleave the phosphateprotecting groups, releasing the active drug. The bioavailabilityof tenofovir is about 35% when administered withfood. The drug is approved by the Food and DrugAdministration (FDA) for the treatment of HIV infectionsin adult patients. Recommendations are for the drug to beadministered with other RT inhibitors or PIs to achievesynergism.

テノホビルジソプロキシル生産企業

201341-05-1, テノホビルジソプロキシルキーワード

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テノホビルジソプロキシル

テノホビルジソプロキシル 化学特性,用途語,生産方法

テノホビルジソプロキシル 生産企業

201341-05-1, テノホビルジソプロキシル キーワード

テノホビルジソプロキシル化学特性,用途語,生産方法

テノホビルジソプロキシル生産企業

201341-05-1, テノホビルジソプロキシルキーワード