モメタゾンフランカルボン酸エステル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P312：気分が悪い時は医師に連絡すること。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

  P362：汚染された衣類を脱ぎ、再使用す場合には洗濯をすること。

  P403+P233：換気の良い場所で保管すること。容器を密閉 しておくこと。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

モメタゾンフランカルボン酸エステル 価格

MSDS Information

• 9-Chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate

モメタゾンフランカルボン酸エステル 化学特性,用途語,生産方法

• 外観

  白色～うすい黄色粉末～結晶

• 効能

  喘息治療薬, 抗炎症薬, グルココルチコイド受容体作動薬

• 商品名

  アズマネックス (MSD); フルメタ (シオノギファーマ)

• 説明

  Mometasone furoate is a topical steroidal antiinflammatory useful in the treatment of corticosteroid-responsive dermatoses. As a steroidal antiinflammatory of grade II potency, mometasone furoate is characterized by a once-daily dose regimen and a relatively wide safety margin.

• 化学的特性

  White-to-Off-White Solid

• 使用

  Mometasone furoate is a deuterated topical corticosteroid used as an anti-inflammatory. Mometasone furoate has been used to study its effect on Leishmania major amastigotes. It could as labeled Mometasone, intended for use as an internal standard for the quantification of Mometasone by GC- or LC-mass spectrometry. Formulations containing mometasone furoate have been used in the treatment of allergic rhinitis, atopic dermatitis, and asthma. Intranasal administration of mometasone furoate (1 μg/nostril) reduces the frequency of sneezing and nasal rubbing in a rat model of histamine-induced allergic rhinitis. Topical application of mometasone furoate reduces croton oil-induced ear edema in mice (ED50 = 0.31 μg/ml).

• 生物学の機能

  Mometasone furoate has strong local anti-inflammatory activity equivalent to that of fluticasone propionate. It has a quick onset of action relative to the other inhaled/intranasal steroids with the least systemic availability and, consequently, the fewest systemic side effects.

• 一般的な説明

  Mometasone furoate (Asmanex,Nasonex) undergoes extensive metabolism to multiplemetabolites. No major metabolites are detectable in humanplasma after oral administration, but the 6β-hydroxy metaboliteis detectable by use of human liver microsomes. Thismetabolite is formed via the CYP3A4 pathway.

• 作用機序

  Mometasone furoate is the most recent glucocorticoid to be developed and commercialized. It has a number of unique functional groups that confer enhanced glucocorticoid activity as well as pharmacokinetic advantages. The combination of the C-21 chloro and the furoic acid ester at C-17 results in the highest glucocorticoid receptor affinity of any topical corticosteroid. The 16α- methyl decreases the mineralocorticoid effects, and the 9α-chloro group increases both glucocorticoid and mineralocorticoid activities. Inhaled mometasone furoate acts locally as an anti-inflammatory treatment for asthma and has the least systemic bioavailability of all the inhaled glucocorticoids (<1%).

• 臨床応用

  Mometasone furoate was originally marketed as a topically applied corticosteroid, but because of its low systemic bioavailability, it was found to be more useful in the treatment of allergic disorders and lung diseases (107).

• 代謝

  It is extensively metabolized, with 6β-hydroxymometasone and 21-hydroxymometasone being found among the metabolites. Inhaled mometasone furoate in mainly excreted in the feces (~74%) as metabolites and only minimally excreted in the urine (~8%). It has a relatively long half-life in the lung and is administered once daily, usually in the evening.

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モメタゾンフランカルボン酸エステル スペクトルデータ(¹HNMR)

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