1-メチルピロリジン化学構造式

1-メチルピロリジン

化学名:1-メチルピロリジン

CAS番号.120-94-5

英語名:1-Methylpyrrolidine

CBNumberCB0672357

MFC5H11N

MW85.15

别名

1-メチルピロリジン

N-メチルピロリジン

Nメチルピロリジン

1-メチルピロリジン物理性質

融点	-90 °C
沸点	76-80 °C (lit.)
比重(密度)	0.800 g/mL at 20 °C (lit.)
蒸気圧	100 hPa (20 °C)
屈折率	n20/D 1.425
闪点	−7 °F
貯蔵温度	Store below +30°C.
溶解性	213g/リットル
外見	液体
酸解離定数(Pka)	10.32(at 25℃)
色	無色透明
PH	11.3 (1g/l, H2O)
爆発限界(explosive limit)	1.1-9.1%(V)
水溶解度	完全に混和
BRN	102445
InChIKey	AVFZOVWCLRSYKC-UHFFFAOYSA-N
LogP	1.1 at 23℃
CAS データベース	120-94-5(CAS DataBase Reference)
NISTの化学物質情報	Pyrrolidine, 1-methyl-(120-94-5)
EPAの化学物質情報	N-Methylpyrrolidine (120-94-5)

安全性情報

危険有害性情報のコード(GHS)

外観
無色～うすい黄色、液体
使用上の注意
不活性ガス封入
化学的特性
colorless transparent volatile liquid. Freely soluble in water, soluble in alcohol, ether and other organic solvents.
使用
1-Methylpyrrolidine is a methylated pyrollidine and is involved as an essential part of the structure of cefipime. It is also an active component of cigarette smoke.
製造方法
n-methylpyrrolidine was successfully synthesized in an aqueous medium by using methylamine and 1,4-dibromobutane in the presence of catalyst k2co3 at a moderated temperature. here, n-methylpyrrolidine was firstly synthesized via the green chemistry process, in which both the water solvent and potassium carbonate catalyst were inexpensive and environmentally friendly. also, the reaction temperature was quite moderated at 90°C.
green organic synthesis of n-methylpyrrolidine
危険性
Flammable, dangerous fire risk. Irritant toskin and eyes.
安全性プロファイル
Poison by intraperitoneal and intravenous routes. This material is strongly alkaline. Liquid and vapors are corrosive to the skin, eyes, or mucous membranes. A very dangerous fire hazard; keep away from sparks, heat sources, and powerful oxidizers. Keep in closed containers. To fight fire, use alcohol foam. When heated to decomposition it emits highly toxic fumes of NOx.
合成
1-Methylpyrrolidine is prepared by hydrogenation of N-Methylpyrrole over Adams' catalyst.