トリフルジモキサジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H360：生殖能または胎児への悪影響のおそれ

  H373：長期にわたる、または反復暴露により臓器の障 害のおそれ

  H400：水生生物に強い毒性

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P273：環境への放出を避けること。

  P314：気分が悪い時は、医師の診断/手当てを受けること。

  P391：漏出物を回収すること。

  P501：内容物/容器を．．．に廃棄すること。

トリフルジモキサジン 化学特性,用途語,生産方法

• 合成

  374.6 g (2.2647 mol) 1,1'-carbonyldiimidazole (98%), 76.4 g (0.7549 mol) triethyamine and 2437 g ethyl acetate were initially charged at 20°C in a stirred vessel. 200 g (0.7549 mol) 6- amino-2,2,7-trifluoro-4-prop-2-yny4H-benzo[1,4]oxazin-3-one (96,7%) were added in portions. The reaction mixture was heated to 55°C At this temperature 95.4 g (0,9064 mol) N,N'-dimethylthiourea (99%) were added. The reaction mixture was stirred at 75-77°C for 25 hours and then poured to a mixture of 2680 ml ice/water and 460 ml hydrochloric acid (32%). The phases were separated and the aqueous phase was extracted twice with 775 ml ethyl acetate. The combined organic phases were dried with Na2SO4 and concentrated to yield 322.9 g. The residue was dissolved in 5970 ml methanol at 65°C 5600 ml methanol were disted off and the remaining suspension was cooled to 0°C. The solid was filtered off and washed with 100 ml cold methanol. The wet solid was dried in a vacuum cabinet at 50°C/10mbar over 24 hours. the desired product trifludimoxazin (determined by quant. HPLC; HPLCmethod A) were isolated. yield 271.0 g, 86.9%.^[2]
  

• 参考文献

  [1] Asher, Brady Scott, et al. Vertical mobility, soil adsorption, and cotton tolerance to three Protoporphyrinogen oxidase (PPO) inhibiting herbicides in three West Texas soils. Texas tech university.
  [2] WOLF B, MAYWALD V,VOGELBACHER UJ, et al. Process formanufacturing triazinon-benzoxazizones: wo，2013092858 [P].2013-06-27.

トリフルジモキサジン 生産企業

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トリフルジモキサジン スペクトルデータ(¹HNMR)

1258836-72-4, トリフルジモキサジン キーワード