N-アセチル-L-システイン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

N-アセチル-L-システイン 価格

MSDS Information

• N-Acetyl-L-(+)-cysteine

N-アセチル-L-システイン 化学特性,用途語,生産方法

• 外観

  白色, 結晶～結晶性粉末

• 定義

  本品は、システイン(*)をアセチル化したものであり、次の化学式で表される。
  参照表示名称：システイン

• 溶解性

  水、エタノール及びアセトンにやや溶けやすい。

• 用途

  SH 基を有する化合物です。 粘液ムコタンパクのジスルフィド結合を解離 する作用を示します。

• 用途

  SH 基を有する化合物です。 粘液ムコタンパクのジスルフィド結合を解離 する作用を示します。

• 化粧品の成分用途

  皮膚コンディショニング剤、酸化防止剤

• 効能

  解毒薬 (アセトアミノフェン), 粘液溶解薬

• 商品名

  アセチルシステイン (あゆみ製薬); ムコフィリン (サンノーバ)

• 説明

  N-Acetyl-L-cysteine is an N-acetylated derivative of cysteine, which contains a sulfhydryl group in the molecule, which can break the disulfide bond (-S-S-) of the mucin peptide bond, so that the mucin chain becomes a small molecule peptide chain, reducing The viscosity of mucin, so It is a dissolving drug for mucus in mucus, purulent sputum and respiratory tract.

• 化学的特性

  N-Acetyl-L-cysteine is a white crystalline powder that has a garlic-like smell and sour taste. It is hygroscopic, and can dissolve in water or ethanol, but is insoluble in ether and chloroform. This substance is also acidic in aqueous solution, with a pH range of 2-2.75 for a concentration of 10g/L H2O.

• 使用

  An antioxidant mucolytic acetylated amino acid.
  N-acetyl-l-cysteine (NAC) is a derivative of the dietary amino acid l-cysteine. NAC has a high affinity for lung tissue, which it supports through mucolytic and antioxidant action. NAC also enhances glutathione production and plays a role in heavy metal detoxification.

• 定義

  ChEBI: N-Acetyl-L-cysteine is an N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine. It is a pharma ceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted.

• 利点

  n-acetyl-l-cysteine is a skin conditioner. It may also be used as an anti-aging ingredient given a demonstrated ability to regulate skin atrophy and reduce the appearance of fine lines and wrinkles.

• 一般的な説明

  N-Acetyl-L-cysteine is the N-acetyl derivative of the amino acid Lcysteine, and is a precursor in the formation of the antioxidant glutathione in the body. The thiol (sulfhydryl) group confers antioxidant effects and is able to reduce free radicals. This compound is sold as a dietary supplement commonly claiming antioxidant and liver protecting effects. It is used as a cough medicine because it breaks disulfide bonds in mucus and liquefies it, making it easier to cough up. It is also this action of breaking disulfide bonds that makes it useful in thinning the abnormally thick mucus in cystic and pulmonary fibrosis patients. In India it is marketed by Intas under the trade name 'Efetil'.

• 作用機序

  N-Acetyl-L-cysteine is a kind of membrane penetrating antioxidant. It has anti-inflammatory activity through regulating the activation of NF-KB and HIF-1α; as well as modulation of ROS. It can penetrate across the membrane, replenishes intracellular and glutathione and GSH to help the cell fight against oxidative stress. In addition to its antioxidant action, NAC acts as a vasodilator by facilitating the production and action of nitric oxide. This property is an important mechanism of action in the prophylaxis of contrast-induced nephropathy and the potentiation of nitrate-induced vasodilation (Millea 2009).

• 副作用

  At dosages of 1,200 mg twice daily or lower, N-acetylcysteine is well tolerated. At these dosages, side effects are unusual, but may include nausea, vomiting, diarrhea, transient skin rash, flushing, epigastric pain, and constipation.
  www.aafp.org

• 安全性プロファイル

  Poison by intraperitoneal route. Moderately toxic by other routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO, and SOx,

• Veterinary Drugs and Treatments

  N-Acetyl-L-cysteine is a mucolytic agent that can be used to stop the melting effect of collagenases and proteases on the cornea. It is useful in halting melting through inhibition of metalloproteinases, but is not felt to be useful for melting caused by infectious agents.

• 参考文献

  http://www.sigmaaldrich.com/catalog/product/sigma/a0737?lang=en&region=US
  Grinberg, L, et al. "N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress." Free Radical Biology & Medicine 38.1(2005):136-145.
  Zhang, Xinsheng, et al. "N-Acetylcysteine Amide Protects Against Methamphetamine-Induced Oxidative Stress and Neurotoxicity in Immortalized Human Brain Endothelial Cells." Brain Research1275(2009):87-95.
  Penugonda, S, et al. "Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12."Brain Research 1056.2(2005):132.
  Lee, Kyung Sun, et al. "A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-|[kappa]|B and hypoxia-inducible factor-1|[alpha]|." Experimental & Molecular Medicine 39.6(2007):756.

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N-アセチル-L-システイン スペクトルデータ(¹HNMR、IR1、IR2、MS、Raman)

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